Expression of SLITRK1 in cancer - Summary - The Human Protein Atlas

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SLITRK1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLITRK1
Gene description	SLIT and NTRK-like family, member 1
Protein class	Disease related genes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Cell line enhanced (A-431, AF22)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. External characterization data supports antibody staining.
Reliability score	Supported based on 1 antibody. HPA012414
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA012414

GENE INFORMATION
Gene name	SLITRK1 (HGNC Symbol)
Synonyms	KIAA1910, LRRC12
Description	SLIT and NTRK-like family, member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Chromosome	13
Cytoband	q31.1
Chromosome location (bp)	83877205 - 83882393
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178235 (version 83.38)
Entrez gene	114798
UniProt	Q96PX8 (UniProt - Evidence at protein level)
neXtProt	NX_Q96PX8
Antibodypedia	SLITRK1 antibodies

PROTEIN BROWSER

SLITRK1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLITRK1-001 ENSP00000366288 ENST00000377084	Q96PX8 [Direct mapping] SLIT and NTRK-like protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007399 [nervous system development] GO:0007409 [axonogenesis] GO:0016021 [integral component of membrane] GO:0030534 [adult behavior] GO:0035264 [multicellular organism growth] GO:0042592 [homeostatic process] GO:0051965 [positive regulation of synapse assembly] Show all	696 aa 77.7 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.