A majority of malignant cells were negative. Weak cytoplasmic positivity was seen in a few cases of urothelial cancers and malignant lymphomas.
SLITRK1 (HGNC Symbol)
SLIT and NTRK-like family, member 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]