Fields »
ABOUT
HELP
BLOG
NEUROG2

GENERAL INFORMATION

Gene name

 NEUROG2

Gene description

 Neurogenin 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (endometrial cancer)
HPA (cell line):Cell line enriched (SH-SY5Y)
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at transcript level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
CAB012342
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (endometrial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB012342

GENE INFORMATION

Gene name

 NEUROG2 (HGNC Symbol)

Synonyms

 Atoh4, bHLHa8, Math4A, ngn-2, NGN2

Description

 Neurogenin 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons. [provided by RefSeq, Apr 2012]

Chromosome

 4

Cytoband

 q25

Chromosome location (bp)

 112513516 - 112516172

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000178403 (version 83.38)

Entrez gene

 63973

UniProt

 Q9H2A3 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9H2A3

Antibodypedia

 NEUROG2 antibodies

PROTEIN BROWSER
NEUROG2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NEUROG2-001
ENSP00000317333
ENST00000313341
Q9H2A3 [Direct mapping]
Neurogenin-2
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Show all
GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0007411 [axon guidance]
GO:0021954 [central nervous system neuron development]
GO:0022008 [neurogenesis]
GO:0030182 [neuron differentiation]
GO:0030900 [forebrain development]
GO:0043565 [sequence-specific DNA binding]
GO:0045165 [cell fate commitment]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0048469 [cell maturation]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0070888 [E-box binding]
Show all
 272 aa
28.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.