Expression of DTX3 in cancer - Summary - The Human Protein Atlas

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DTX3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DTX3
Gene description	Deltex 3, E3 ubiquitin ligase
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 1 antibody. HPA059654
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and lung cancer (favourable).
Pancreatic cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA059654

GENE INFORMATION
Gene name	DTX3 (HGNC Symbol)
Synonyms	FLJ34766, RNF154
Description	Deltex 3, E3 ubiquitin ligase (HGNC Symbol)
Entrez gene summary	DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
Chromosome	12
Cytoband	q13.3
Chromosome location (bp)	57604622 - 57609804
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178498 (version 83.38)
Entrez gene	196403
UniProt	Q8N9I9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N9I9
Antibodypedia	DTX3 antibodies

PROTEIN BROWSER

DTX3-001	DTX3-002	DTX3-003	DTX3-004	DTX3-005	DTX3-006	DTX3-007	DTX3-008	DTX3-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DTX3-001 ENSP00000449294 ENST00000548804	Q8N9I9 [Direct mapping] Probable E3 ubiquitin-protein ligase DTX3 A0A024RB96 [Target identity:100%; Query identity:100%] Deltex 3 homolog (Drosophila), isoform CRA_b Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] Show all	347 aa 38 kDa	No	0
DTX3-002 ENSP00000338050 ENST00000337737	Q8N9I9 [Direct mapping] Probable E3 ubiquitin-protein ligase DTX3 A0A024RB96 [Target identity:100%; Query identity:100%] Deltex 3 homolog (Drosophila), isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] Show all	347 aa 38 kDa	No	0
DTX3-003 ENSP00000447873 ENST00000548198	Q8N9I9 [Direct mapping] Probable E3 ubiquitin-protein ligase DTX3 A0A024RB96 [Target identity:100%; Query identity:100%] Deltex 3 homolog (Drosophila), isoform CRA_b Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] Show all	347 aa 38 kDa	No	0
DTX3-004 ENSP00000448224 ENST00000548478	A0A0C4DGI8 [Direct mapping] Probable E3 ubiquitin-protein ligase DTX3 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	194 aa 20.9 kDa	No	0
DTX3-005 ENSP00000449688 ENST00000549583	F8VUZ4 [Direct mapping] Probable E3 ubiquitin-protein ligase DTX3 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	204 aa 21.9 kDa	No	0
DTX3-006 ENSP00000448696 ENST00000551632	Q8N9I9 [Direct mapping] Probable E3 ubiquitin-protein ligase DTX3 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] Show all	350 aa 38.2 kDa	No	0
DTX3-007 ENSP00000449118 ENST00000550596		Predicted intracellular proteins Show all		7 aa 0.7 kDa	No	0
DTX3-008 ENSP00000449950 ENST00000551835	F8VV96 [Direct mapping] Probable E3 ubiquitin-protein ligase DTX3 Show all	Predicted intracellular proteins Show all		49 aa 5.5 kDa	No	0
DTX3-009 ENSP00000446996 ENST00000550300	H0YHF9 [Direct mapping] Probable E3 ubiquitin-protein ligase DTX3 Show all	Predicted intracellular proteins Show all		172 aa 19.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.