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Gene name

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Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

Tissue

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Expression

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Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

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Antibodies

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ERBB4
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ERBB4

Gene description

Erb-b2 receptor tyrosine kinase 4

Protein class

Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enhanced (breast cancer)
HPA (cell line):Group enriched (AF22, EFO-21, HEK93, RPTEC TERT1, SCLC-21H, T-47d)
HPA (normal tissue):Tissue enhanced (fallopian tube)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear and cytoplasmic staining.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 3 antibodies.
HPA012016 , CAB000276 , CAB025522
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enhanced (breast cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA012016
CAB000276
CAB025522

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignancies showed weak to moderate nuclear positivity.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignancies were generally negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant cells displayed weak to moderate nuclear immunoreactivity. Several cases of malignant lymphomas and gliomas as well as ovarian cancers were negative.

GENE INFORMATION

Gene name

ERBB4 (HGNC Symbol)

Synonyms

ALS19, HER4

Description

Erb-b2 receptor tyrosine kinase 4 (HGNC Symbol)

Entrez gene summary

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q34

Chromosome location (bp)

211375717 - 212538841

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000178568 (version 83.38)

Entrez gene

2066

UniProt

Q15303 (UniProt - Evidence at protein level)

neXtProt

NX_Q15303

Antibodypedia

ERBB4 antibodies

PROTEIN BROWSER

ERBB4-001
ERBB4-002
ERBB4-004
ERBB4-005
ERBB4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ERBB4-001
ENSP00000342235
ENST00000342788
Q15303 [Direct mapping]
Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001755 [neural crest cell migration]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007507 [heart development]
GO:0007595 [lactation]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009880 [embryonic pattern specification]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021551 [central nervous system morphogenesis]
GO:0021889 [olfactory bulb interneuron differentiation]
GO:0030334 [regulation of cell migration]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060644 [mammary gland epithelial cell differentiation]
GO:0060749 [mammary gland alveolus development]
GO:0061026 [cardiac muscle tissue regeneration]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:2000010 [positive regulation of protein localization to cell surface]
GO:2000366 [positive regulation of STAT protein import into nucleus]
GO:2001223 [negative regulation of neuron migration]
Show all
1308 aa
146.8 kDa
Yes 1
ERBB4-002
ENSP00000403204
ENST00000436443
Q15303 [Direct mapping]
Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001755 [neural crest cell migration]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007507 [heart development]
GO:0007595 [lactation]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009880 [embryonic pattern specification]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021551 [central nervous system morphogenesis]
GO:0021889 [olfactory bulb interneuron differentiation]
GO:0030334 [regulation of cell migration]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060644 [mammary gland epithelial cell differentiation]
GO:0060749 [mammary gland alveolus development]
GO:0061026 [cardiac muscle tissue regeneration]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:2000366 [positive regulation of STAT protein import into nucleus]
Show all
1292 aa
145.2 kDa
Yes 1
ERBB4-004
ENSP00000260943
ENST00000260943
H3BLT0 [Direct mapping]
Receptor tyrosine-protein kinase erbB-4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
731 aa
80.9 kDa
Yes 1
ERBB4-005
ENSP00000405564
ENST00000435846
E9PDR1 [Direct mapping]
Receptor tyrosine-protein kinase erbB-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
128 aa
14.6 kDa
No 0
ERBB4-201
ENSP00000385565
ENST00000402597
A0A0A0MSE1 [Direct mapping]
Receptor protein-tyrosine kinase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0023014 [signal transduction by protein phosphorylation]
Show all
1249 aa
140.3 kDa
No 1

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