O75460 [Direct mapping]
Serine/threonine-protein kinase/endoribonuclease IRE1 Serine/threonine-protein kinase Endoribonuclease

GO:0000287 [magnesium ion binding]
GO:0001935 [endothelial cell proliferation]
GO:0004519 [endonuclease activity]
GO:0004521 [endoribonuclease activity]
GO:0004540 [ribonuclease activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005637 [nuclear inner membrane]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006379 [mRNA cleavage]
GO:0006397 [mRNA processing]
GO:0006402 [mRNA catabolic process]
GO:0006468 [protein phosphorylation]
GO:0006987 [activation of signaling protein activity involved in unfolded protein response]
GO:0007050 [cell cycle arrest]
GO:0007257 [activation of JUN kinase activity]
GO:0016241 [regulation of macroautophagy]
GO:0019899 [enzyme binding]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030544 [Hsp70 protein binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0033120 [positive regulation of RNA splicing]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036289 [peptidyl-serine autophosphorylation]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043531 [ADP binding]
GO:0044267 [cellular protein metabolic process]
GO:0046777 [protein autophosphorylation]
GO:0051879 [Hsp90 protein binding]
GO:0070054 [mRNA splicing, via endonucleolytic cleavage and ligation]
GO:0070055 [mRNA endonucleolytic cleavage involved in unfolded protein response]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0071333 [cellular response to glucose stimulus]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response]
GO:1901142 [insulin metabolic process]
GO:1990332 [Ire1 complex]
GO:1990579 [peptidyl-serine trans-autophosphorylation]
GO:1990597 [AIP1-IRE1 complex]
GO:1990604 [IRE1-TRAF2-ASK1 complex]
GO:1990630 [IRE1-RACK1-PP2A complex]