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RPP25

GENERAL INFORMATION

Gene name

 RPP25

Gene description

 Ribonuclease P/MRP 25kDa subunit

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (SCLC-21H, SK-MEL-30)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA046900
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable).
Glioma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA046900

GENE INFORMATION

Gene name

 RPP25 (HGNC Symbol)

Synonyms

 FLJ20374

Description

 Ribonuclease P/MRP 25kDa subunit (HGNC Symbol)

Entrez gene summary

Chromosome

 15

Cytoband

 q24.2

Chromosome location (bp)

 74954416 - 74957464

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178718 (version 83.38)

Entrez gene

 54913

UniProt

 Q9BUL9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BUL9

Antibodypedia

 RPP25 antibodies

PROTEIN BROWSER
RPP25-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPP25-001
ENSP00000317691
ENST00000322177
Q9BUL9 [Direct mapping]
Ribonuclease P protein subunit p25
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0004526 [ribonuclease P activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005815 [microtubule organizing center]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0044822 [poly(A) RNA binding]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
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 199 aa
20.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.