Expression of MPI in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MPI
Gene description	Mannose phosphate isomerase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	18
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA007200
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable).
Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA007200

GENE INFORMATION
Gene name	MPI
Synonyms
Description	Mannose phosphate isomerase (HGNC Symbol)
Entrez gene summary	Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Chromosome	15
Cytoband
Chromosome location (bp)	74890005 - 74902219
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178802 (version 83.38)
Entrez gene	4351
UniProt	P34949 (UniProt - Evidence at protein level)
neXtProt	NX_P34949
Antibodypedia	MPI antibodies

PROTEIN BROWSER

MPI-001	MPI-002	MPI-003	MPI-004	MPI-005	MPI-006	MPI-008	MPI-010	MPI-012	MPI-013	MPI-014	MPI-015	MPI-018	MPI-019	MPI-021	MPI-022	MPI-023	MPI-024

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MPI-001 ENSP00000318318 ENST00000352410	P34949 [Direct mapping] Mannose-6-phosphate isomerase Show all	Enzymes ENZYME proteins Isomerase MEMSAT3 predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004476 [mannose-6-phosphate isomerase activity] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0008270 [zinc ion binding] GO:0009298 [GDP-mannose biosynthetic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0061611 [mannose to fructose-6-phosphate metabolic process] GO:0070062 [extracellular exosome] Show all	423 aa 46.7 kDa	No	0
MPI-002 ENSP00000440447 ENST00000535694	F5GX71 [Direct mapping] Mannose-6-phosphate isomerase Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004476 [mannose-6-phosphate isomerase activity] GO:0005975 [carbohydrate metabolic process] GO:0008270 [zinc ion binding] GO:0009298 [GDP-mannose biosynthetic process] Show all	373 aa 41.2 kDa	No	0
MPI-003 ENSP00000455405 ENST00000566377	H3BPP3 [Direct mapping] Mannose-6-phosphate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004476 [mannose-6-phosphate isomerase activity] GO:0005975 [carbohydrate metabolic process] GO:0008270 [zinc ion binding] GO:0009298 [GDP-mannose biosynthetic process] Show all	287 aa 31.9 kDa	No	0
MPI-004 ENSP00000454312 ENST00000564003	B4DYB8 [Direct mapping] Mannose-6-phosphate isomerase; cDNA FLJ54812, moderately similar to Mannose-6-phosphate isomerase (EC 5.3.1.8) Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004476 [mannose-6-phosphate isomerase activity] GO:0005975 [carbohydrate metabolic process] GO:0008270 [zinc ion binding] GO:0009298 [GDP-mannose biosynthetic process] Show all	228 aa 25.4 kDa	No	0
MPI-005 ENSP00000457885 ENST00000563422	H3BUZ9 [Direct mapping] Mannose-6-phosphate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004476 [mannose-6-phosphate isomerase activity] GO:0005975 [carbohydrate metabolic process] GO:0008270 [zinc ion binding] GO:0009298 [GDP-mannose biosynthetic process] Show all	339 aa 37.7 kDa	No	0
MPI-006 ENSP00000455241 ENST00000563786	H3BPB8 [Direct mapping] Mannose-6-phosphate isomerase Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004476 [mannose-6-phosphate isomerase activity] GO:0005975 [carbohydrate metabolic process] GO:0008270 [zinc ion binding] GO:0009298 [GDP-mannose biosynthetic process] Show all	403 aa 44.4 kDa	No	0
MPI-008 ENSP00000318192 ENST00000323744	P34949 [Direct mapping] Mannose-6-phosphate isomerase Show all	Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004476 [mannose-6-phosphate isomerase activity] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0008270 [zinc ion binding] GO:0009298 [GDP-mannose biosynthetic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	362 aa 39.8 kDa	No	0
MPI-010 ENSP00000454622 ENST00000569233	H3BN01 [Direct mapping] Mannose-6-phosphate isomerase Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004476 [mannose-6-phosphate isomerase activity] GO:0005975 [carbohydrate metabolic process] GO:0008270 [zinc ion binding] GO:0009298 [GDP-mannose biosynthetic process] Show all	174 aa 19.4 kDa	No	0
MPI-012 ENSP00000455477 ENST00000567570	H3BPU7 [Direct mapping] Mannose-6-phosphate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004476 [mannose-6-phosphate isomerase activity] GO:0005975 [carbohydrate metabolic process] GO:0008270 [zinc ion binding] GO:0009298 [GDP-mannose biosynthetic process] Show all	119 aa 13.2 kDa	No	0
MPI-013 ENSP00000457020 ENST00000562606	H3BT48 [Direct mapping] Mannose-6-phosphate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004476 [mannose-6-phosphate isomerase activity] GO:0005975 [carbohydrate metabolic process] GO:0008270 [zinc ion binding] GO:0009298 [GDP-mannose biosynthetic process] Show all	319 aa 35.5 kDa	No	0
MPI-014 ENSP00000455161 ENST00000569931	H3BP57 [Direct mapping] Mannose-6-phosphate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004476 [mannose-6-phosphate isomerase activity] GO:0005975 [carbohydrate metabolic process] GO:0008270 [zinc ion binding] GO:0009298 [GDP-mannose biosynthetic process] Show all	288 aa 31.9 kDa	No	0
MPI-015 ENSP00000454619 ENST00000565576	H3BMZ9 [Direct mapping] Mannose-6-phosphate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004476 [mannose-6-phosphate isomerase activity] GO:0005975 [carbohydrate metabolic process] GO:0008270 [zinc ion binding] GO:0009298 [GDP-mannose biosynthetic process] Show all	264 aa 29.3 kDa	No	0
MPI-018 ENSP00000457494 ENST00000568907	H3BU66 [Direct mapping] Mannose-6-phosphate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004476 [mannose-6-phosphate isomerase activity] GO:0005975 [carbohydrate metabolic process] GO:0008270 [zinc ion binding] GO:0009298 [GDP-mannose biosynthetic process] Show all	168 aa 18.6 kDa	No	0
MPI-019 ENSP00000455065 ENST00000568828	H3BNY8 [Direct mapping] Mannose-6-phosphate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004476 [mannose-6-phosphate isomerase activity] GO:0005975 [carbohydrate metabolic process] GO:0008270 [zinc ion binding] GO:0009298 [GDP-mannose biosynthetic process] Show all	185 aa 20.4 kDa	No	0
MPI-021 ENSP00000455972 ENST00000567132	H3BQX0 [Direct mapping] Mannose-6-phosphate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004476 [mannose-6-phosphate isomerase activity] GO:0005975 [carbohydrate metabolic process] GO:0008270 [zinc ion binding] GO:0009298 [GDP-mannose biosynthetic process] Show all	176 aa 19.5 kDa	No	0
MPI-022 ENSP00000455383 ENST00000564633	H3BPM5 [Direct mapping] Mannose-6-phosphate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004476 [mannose-6-phosphate isomerase activity] GO:0005975 [carbohydrate metabolic process] GO:0008270 [zinc ion binding] GO:0009298 [GDP-mannose biosynthetic process] Show all	173 aa 19.1 kDa	No	0
MPI-023 ENSP00000457013 ENST00000567177	H3BT46 [Direct mapping] Mannose-6-phosphate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004476 [mannose-6-phosphate isomerase activity] GO:0005975 [carbohydrate metabolic process] GO:0008270 [zinc ion binding] GO:0009298 [GDP-mannose biosynthetic process] Show all	213 aa 23.7 kDa	No	0
MPI-024 ENSP00000457619 ENST00000562800	H3BUG1 [Direct mapping] Mannose-6-phosphate isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004476 [mannose-6-phosphate isomerase activity] GO:0005975 [carbohydrate metabolic process] GO:0008270 [zinc ion binding] GO:0009298 [GDP-mannose biosynthetic process] Show all	125 aa 13.4 kDa	No	0