Fields »
ABOUT
HELP
BLOG
MSC

GENERAL INFORMATION

Gene name

 MSC

Gene description

 Musculin

Protein class

 Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enriched (HDLM-2)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and glioma (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Glioma p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 MSC (HGNC Symbol)

Synonyms

 ABF-1, bHLHa22

Description

 Musculin (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q13.3

Chromosome location (bp)

 71841549 - 71844468

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178860 (version 83.38)

Entrez gene

 9242

UniProt

 O60682 (UniProt - Evidence at protein level)

neXtProt

 NX_O60682

Antibodypedia

 MSC antibodies

PROTEIN BROWSER
MSC-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MSC-001
ENSP00000321445
ENST00000325509
O60682 [Direct mapping]
Musculin
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Basic domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001206 [transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005634 [nucleus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0014707 [branchiomeric skeletal muscle development]
GO:0046983 [protein dimerization activity]
GO:0060021 [palate development]
GO:0060539 [diaphragm development]
Show all
 206 aa
22.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.