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APOLD1

GENERAL INFORMATION

Gene name

 APOLD1

Gene description

 Apolipoprotein L domain containing 1

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AF22, HDLM-2)
HPA (normal tissue):Tissue enhanced (adipose tissue)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in most tissues, including placenta.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA052462
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA052462

GENE INFORMATION

Gene name

 APOLD1 (HGNC Symbol)

Synonyms

 DKFZP434F0318, FLJ25138

Description

 Apolipoprotein L domain containing 1 (HGNC Symbol)

Entrez gene summary

 APOLD1 is an endothelial cell early response protein that may play a role in regulation of endothelial cell signaling and vascular function (Regard et al., 2004 [PubMed 15102925]).[supplied by OMIM, Dec 2008]

Chromosome

 12

Cytoband

 p13.1

Chromosome location (bp)

 12725917 - 12829975

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178878 (version 83.38)

Entrez gene

 81575

UniProt

 Q96LR9 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q96LR9

Antibodypedia

 APOLD1 antibodies

PROTEIN BROWSER
APOLD1-001
APOLD1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APOLD1-001
ENSP00000324277
ENST00000326765
Q96LR9 [Direct mapping]
Apolipoprotein L domain-containing protein 1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
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GO:0001525 [angiogenesis]
GO:0001666 [response to hypoxia]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0016021 [integral component of membrane]
GO:0030154 [cell differentiation]
GO:0042118 [endothelial cell activation]
GO:0042157 [lipoprotein metabolic process]
GO:0045601 [regulation of endothelial cell differentiation]
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 279 aa
30.5 kDa 		No 3
APOLD1-002
ENSP00000348998
ENST00000356591
Q96LR9 [Direct mapping]
Apolipoprotein L domain-containing protein 1
A0AVN6 [Target identity:100%; Query identity:100%]
Apolipoprotein L domain containing 1; HCG1658737, isoform CRA_b; cDNA, FLJ95166
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0016021 [integral component of membrane]
GO:0030154 [cell differentiation]
GO:0042157 [lipoprotein metabolic process]
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 248 aa
27.1 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.