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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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APOLD1
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

APOLD1

Gene description

Apolipoprotein L domain containing 1

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AF22, HDLM-2)
HPA (normal tissue):Tissue enhanced (adipose tissue)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in most tissues, including placenta.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA052462
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA052462

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues showed weak to moderate cytoplasmic immunoreactivity. Additional/or nuclear staining was displayed in gliomas, renal and few cervical cancers. Several lymphomas and basal cell carcinomas were negative.

GENE INFORMATION

Gene name

APOLD1 (HGNC Symbol)

Synonyms

DKFZP434F0318, FLJ25138

Description

Apolipoprotein L domain containing 1 (HGNC Symbol)

Entrez gene summary

APOLD1 is an endothelial cell early response protein that may play a role in regulation of endothelial cell signaling and vascular function (Regard et al., 2004 [PubMed 15102925]).[supplied by OMIM, Dec 2008]

Chromosome

12

Cytoband

p13.1

Chromosome location (bp)

12725917 - 12829975

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000178878 (version 83.38)

Entrez gene

81575

UniProt

Q96LR9 (UniProt - Evidence at transcript level)

neXtProt

NX_Q96LR9

Antibodypedia

APOLD1 antibodies

PROTEIN BROWSER

APOLD1-001
APOLD1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APOLD1-001
ENSP00000324277
ENST00000326765
Q96LR9 [Direct mapping]
Apolipoprotein L domain-containing protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0001525 [angiogenesis]
GO:0001666 [response to hypoxia]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0016021 [integral component of membrane]
GO:0030154 [cell differentiation]
GO:0042118 [endothelial cell activation]
GO:0042157 [lipoprotein metabolic process]
GO:0045601 [regulation of endothelial cell differentiation]
Show all
279 aa
30.5 kDa
No 3
APOLD1-002
ENSP00000348998
ENST00000356591
Q96LR9 [Direct mapping]
Apolipoprotein L domain-containing protein 1
A0AVN6 [Target identity:100%; Query identity:100%]
Apolipoprotein L domain containing 1; HCG1658737, isoform CRA_b; cDNA, FLJ95166
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0016021 [integral component of membrane]
GO:0030154 [cell differentiation]
GO:0042157 [lipoprotein metabolic process]
Show all
248 aa
27.1 kDa
No 3

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