Expression of DPY19L3 in cancer - Summary - The Human Protein Atlas

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DPY19L3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DPY19L3
Gene description	Dpy-19-like 3 (C. elegans)
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA008325
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and head and neck cancer (favourable).
Pancreatic cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008325

GENE INFORMATION
Gene name	DPY19L3
Synonyms
Description	Dpy-19-like 3 (C. elegans) (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.11
Chromosome location (bp)	32405543 - 32485895
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178904 (version 83.38)
Entrez gene	147991
UniProt	Q6ZPD9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6ZPD9
Antibodypedia	DPY19L3 antibodies

PROTEIN BROWSER

DPY19L3-001	DPY19L3-002	DPY19L3-003	DPY19L3-007	DPY19L3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DPY19L3-001 ENSP00000344937 ENST00000342179	Q6ZPD9 [Direct mapping] Probable C-mannosyltransferase DPY19L3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0005637 [nuclear inner membrane] GO:0016021 [integral component of membrane] GO:0018406 [protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan] Show all	716 aa 83.2 kDa	No	>9
DPY19L3-002 ENSP00000466062 ENST00000586427	K7ELG1 [Direct mapping] Probable C-mannosyltransferase DPY19L3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0005637 [nuclear inner membrane] GO:0016021 [integral component of membrane] GO:0018406 [protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan] Show all	126 aa 14.6 kDa	No	1
DPY19L3-003 ENSP00000465995 ENST00000587077	Q8N6Q4 [Direct mapping] Dpy-19-like 3 (C. elegans); Probable C-mannosyltransferase DPY19L3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0005637 [nuclear inner membrane] GO:0016021 [integral component of membrane] GO:0018406 [protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan] Show all	102 aa 11.6 kDa	No	1
DPY19L3-007 ENSP00000466086 ENST00000586987	K7ELH8 [Direct mapping] Probable C-mannosyltransferase DPY19L3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0005637 [nuclear inner membrane] GO:0016021 [integral component of membrane] GO:0018406 [protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan] Show all	688 aa 79.5 kDa	No	>9
DPY19L3-201 ENSP00000376081 ENST00000392250	Q6ZPD9 [Direct mapping] Probable C-mannosyltransferase DPY19L3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0005637 [nuclear inner membrane] GO:0016021 [integral component of membrane] GO:0018406 [protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan] Show all	716 aa 83.2 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.