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Moderate to strong nuclear staining in almost all malignant tissues. Strongest staining in cervical, lung, urothelial, renal and stomach cancers. Tumors of the liver exhibited differences in intensities depending of tumor type, hepatocellular tumors were virtually negative or weakly stained while cholangiocarcinomas showed distinct positivity.
GENE INFORMATION
Gene name
TAF7 (HGNC Symbol)
Synonyms
TAF2F, TAFII55
Description
TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa (HGNC Symbol)
Entrez gene summary
The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II. [provided by RefSeq, Jul 2008]