Fields »
ABOUT
HELP
BLOG
TUFM

GENERAL INFORMATION

Gene name

 TUFM

Gene description

 Tu translation elongation factor, mitochondrial

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA018991 , HPA024087 , CAB075730 , CAB075731
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TUFM (HGNC Symbol)

Synonyms

 EF-TuMT, EFTu

Description

 Tu translation elongation factor, mitochondrial (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 p11.2

Chromosome location (bp)

 28842411 - 28846408

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178952 (version 83.38)

Entrez gene

 7284

UniProt

 P49411 (UniProt - Evidence at protein level)

neXtProt

 NX_P49411

Antibodypedia

 TUFM antibodies

PROTEIN BROWSER
TUFM-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TUFM-001
ENSP00000322439
ENST00000313511
P49411 [Direct mapping]
Elongation factor Tu, mitochondrial
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0006414 [translational elongation]
GO:0006996 [organelle organization]
GO:0016020 [membrane]
GO:0032543 [mitochondrial translation]
GO:0042645 [mitochondrial nucleoid]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
GO:0070125 [mitochondrial translational elongation]
Show all
 455 aa
49.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.