Expression of ERICH3 in cancer - Summary - The Human Protein Atlas

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ERICH3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ERICH3
Gene description	Glutamate-rich 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (endometrial cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (cerebral cortex, fallopian tube, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in cilia of fallopian tube and respiratory epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded. Protein expression in respiratory epithelia can be correlated with lung RNA-seq data.
Reliability score	Approved based on 1 antibody. HPA028655
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (endometrial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA028655

GENE INFORMATION
Gene name	ERICH3 (HGNC Symbol)
Synonyms	C1orf173, DKFZp547I048, RP11-653A5.1
Description	Glutamate-rich 3 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p31.1
Chromosome location (bp)	74568111 - 74673738
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178965 (version 83.38)
Entrez gene	127254
UniProt	Q5RHP9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5RHP9
Antibodypedia	ERICH3 antibodies

PROTEIN BROWSER

ERICH3-001	ERICH3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ERICH3-001 ENSP00000322609 ENST00000326665	Q5RHP9 [Direct mapping] Glutamate-rich protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		1530 aa 168.5 kDa	No	0
ERICH3-002 ENSP00000398581 ENST00000420661	Q5RHP9 [Direct mapping] Glutamate-rich protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		533 aa 60.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.