We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described. [provided by RefSeq, Jan 2014]
O15534 [Direct mapping] Period circadian protein homolog 1
Show all
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000989 [transcription factor activity, transcription factor binding] GO:0002028 [regulation of sodium ion transport] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007623 [circadian rhythm] GO:0009649 [entrainment of circadian clock] GO:0010608 [posttranscriptional regulation of gene expression] GO:0019900 [kinase binding] GO:0031490 [chromatin DNA binding] GO:0031625 [ubiquitin protein ligase binding] GO:0032922 [circadian regulation of gene expression] GO:0042634 [regulation of hair cycle] GO:0042752 [regulation of circadian rhythm] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043966 [histone H3 acetylation] GO:0043967 [histone H4 acetylation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046329 [negative regulation of JNK cascade] GO:0070888 [E-box binding] GO:0070932 [histone H3 deacetylation] GO:0097167 [circadian regulation of translation] GO:1900015 [regulation of cytokine production involved in inflammatory response] GO:1900744 [regulation of p38MAPK cascade] GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
J3KSL6 [Direct mapping] Period circadian protein homolog 1
Show all
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
J3QL55 [Direct mapping] Period circadian protein homolog 1
Show all
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
J3QLQ5 [Direct mapping] Period circadian protein homolog 1
Show all
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
J3QL46 [Direct mapping] Period circadian protein homolog 1
Show all
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)