Expression of HTR1F in cancer - Summary - The Human Protein Atlas

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HTR1F

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HTR1F
Gene description	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
Protein class	FDA approved drug targets G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (K-562, LHCN-M2)
HPA (normal tissue):	Tissue enhanced (placenta)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results.
Reliability score	Uncertain based on 1 antibody. HPA005555
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA005555

GENE INFORMATION
Gene name	HTR1F (HGNC Symbol)
Synonyms	5-HT1F, HTR1EL
Description	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p11.1
Chromosome location (bp)	87990696 - 87993835
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000179097 (version 83.38)
Entrez gene	3355
UniProt	P30939 (UniProt - Evidence at transcript level)
neXtProt	NX_P30939
Antibodypedia	HTR1F antibodies

PROTEIN BROWSER

HTR1F-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HTR1F-001 ENSP00000322924 ENST00000319595	P30939 [Direct mapping] 5-hydroxytryptamine receptor 1F Show all	G-protein coupled receptors GPCRs excl olfactory receptors Serotonin receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004993 [serotonin receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007210 [serotonin receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0016021 [integral component of membrane] GO:0051378 [serotonin binding] Show all	366 aa 41.7 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.