Cell atlas - HES7 - The Human Protein Atlas

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HES7

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleoplasm

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	HES7
Gene description	Hes family bHLH transcription factor 7
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the nucleoli.
RNA cell category	Cell line enhanced (HeLa, HDLM-2, A-431)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Nucleoli (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA072105
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HeLa, HDLM-2, A-431) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the nucleoli.

Main location

Nucleoplasm (approved)

Additional location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA072105	HeLa	Nucleoplasm
	HPA072105	U-2 OS	Nucleoplasm
	HPA072105	U-2 OS	Nucleoli	Spatial

GENE INFORMATION
Gene name	HES7 (HGNC Symbol)
Synonyms	bHLHb37
Description	Hes family bHLH transcription factor 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	8120590 - 8124092
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179111 (version 83.38)
Entrez gene	84667
UniProt	Q9BYE0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BYE0
Antibodypedia	HES7 antibodies

PROTEIN BROWSER

HES7-001	HES7-002	HES7-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HES7-001 ENSP00000446205 ENST00000541682	Q9BYE0 [Direct mapping] Transcription factor HES-7 Show all	Predicted intracellular proteins Transcription factors Basic domains Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001501 [skeletal system development] GO:0001756 [somitogenesis] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007219 [Notch signaling pathway] GO:0007498 [mesoderm development] GO:0008134 [transcription factor binding] GO:0014807 [regulation of somitogenesis] GO:0036342 [post-anal tail morphogenesis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity] GO:0048511 [rhythmic process] Show all	230 aa 25.3 kDa	No	0
HES7-002 ENSP00000314774 ENST00000317814	Q9BYE0 [Direct mapping] Transcription factor HES-7 Show all	Predicted intracellular proteins Transcription factors Basic domains Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007498 [mesoderm development] GO:0008134 [transcription factor binding] GO:0046983 [protein dimerization activity] Show all	225 aa 24.9 kDa	No	0
HES7-003 ENSP00000462491 ENST00000577735	J3KSH6 [Direct mapping] Transcription factor HES-7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity] Show all	145 aa 16.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.