Expression of SAMD4B in cancer - Summary - The Human Protein Atlas

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SAMD4B

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SAMD4B
Gene description	Sterile alpha motif domain containing 4B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA016800
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA016800

GENE INFORMATION
Gene name	SAMD4B (HGNC Symbol)
Synonyms	FLJ10211, hSmaug2, MGC99832, SMGB
Description	Sterile alpha motif domain containing 4B (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	39342396 - 39385710
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179134 (version 83.38)
Entrez gene	55095
UniProt	Q5PRF9 (UniProt - Evidence at protein level)
neXtProt	NX_Q5PRF9
Antibodypedia	SAMD4B antibodies

PROTEIN BROWSER

SAMD4B-001	SAMD4B-002	SAMD4B-004	SAMD4B-007	SAMD4B-008	SAMD4B-009	SAMD4B-012	SAMD4B-201	SAMD4B-202	SAMD4B-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SAMD4B-001 ENSP00000317224 ENST00000314471	Q5PRF9 [Direct mapping] Protein Smaug homolog 2 A0A024R0N7 [Target identity:100%; Query identity:100%] Sterile alpha motif domain containing 4B, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0044822 [poly(A) RNA binding] Show all	694 aa 75.5 kDa	No	0
SAMD4B-002 ENSP00000470237 ENST00000598913	M0QZ22 [Direct mapping] Protein Smaug homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] Show all	692 aa 75.3 kDa	No	0
SAMD4B-004 ENSP00000471509 ENST00000596368	M0R0X3 [Direct mapping] Protein Smaug homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	325 aa 35.8 kDa	No	0
SAMD4B-007 ENSP00000470821 ENST00000600018	M0QZW7 [Direct mapping] Protein Smaug homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	48 aa 5.5 kDa	No	0
SAMD4B-008 ENSP00000469620 ENST00000599712	M0QY61 [Direct mapping] Protein Smaug homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	219 aa 24.4 kDa	No	0
SAMD4B-009 ENSP00000469404 ENST00000602243	M0QXV2 [Direct mapping] Protein Smaug homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		75 aa 8.6 kDa	No	0
SAMD4B-012 ENSP00000468891 ENST00000598605	M0QX45 [Direct mapping] Protein Smaug homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		94 aa 9.9 kDa	No	0
SAMD4B-201 ENSP00000484229 ENST00000610417	Q5PRF9 [Direct mapping] Protein Smaug homolog 2 A0A024R0N7 [Target identity:100%; Query identity:100%] Sterile alpha motif domain containing 4B, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0044822 [poly(A) RNA binding] Show all	694 aa 75.5 kDa	No	0
SAMD4B-202 ENSP00000482861 ENST00000611159	A0A087WZT0 [Direct mapping] Protein Smaug homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	663 aa 72.4 kDa	No	0
SAMD4B-203 ENSP00000478730 ENST00000614559	A0A087WUK6 [Direct mapping] Protein Smaug homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	663 aa 72.5 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.