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CYP11B2

GENERAL INFORMATION

Gene name

 CYP11B2

Gene description

 Cytochrome P450, family 11, subfamily B, polypeptide 2

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (adrenal gland)
GTEx:Tissue enriched (adrenal gland)

Protein evidence

 Evidence at protein level

Protein expression

 Selective granular cytoplasmic expression in adrenal gland.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 3 antibodies.
HPA049171 , HPA056348 , HPA057752
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adrenal gland)

GENE INFORMATION

Gene name

 CYP11B2 (HGNC Symbol)

Synonyms

 ALDOS, CPN2, CYP11B, CYP11BL, P-450C18, P450aldo

Description

 Cytochrome P450, family 11, subfamily B, polypeptide 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q24.3

Chromosome location (bp)

 142910559 - 142917843

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179142 (version 83.38)

Entrez gene

 1585

UniProt

 P19099 (UniProt - Evidence at protein level)

neXtProt

 NX_P19099

Antibodypedia

 CYP11B2 antibodies

PROTEIN BROWSER
CYP11B2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYP11B2-001
ENSP00000325822
ENST00000323110
P19099 [Direct mapping]
Cytochrome P450 11B2, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0002017 [regulation of blood volume by renal aldosterone]
GO:0003091 [renal water homeostasis]
GO:0004507 [steroid 11-beta-monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006700 [C21-steroid hormone biosynthetic process]
GO:0006705 [mineralocorticoid biosynthetic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008202 [steroid metabolic process]
GO:0008203 [cholesterol metabolic process]
GO:0016125 [sterol metabolic process]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen]
GO:0020037 [heme binding]
GO:0032342 [aldosterone biosynthetic process]
GO:0032870 [cellular response to hormone stimulus]
GO:0034651 [cortisol biosynthetic process]
GO:0035865 [cellular response to potassium ion]
GO:0044281 [small molecule metabolic process]
GO:0044550 [secondary metabolite biosynthetic process]
GO:0047783 [corticosterone 18-monooxygenase activity]
GO:0055075 [potassium ion homeostasis]
GO:0055078 [sodium ion homeostasis]
GO:0055114 [oxidation-reduction process]
GO:0071375 [cellular response to peptide hormone stimulus]
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 503 aa
57.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.