Expression of EDC3 in cancer - Summary - The Human Protein Atlas

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EDC3

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	EDC3
Gene description	Enhancer of mRNA decapping 3
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA040650 , HPA044206
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040650	HPA044206

GENE INFORMATION
Gene name	EDC3 (HGNC Symbol)
Synonyms	FLJ21128, hYjeF_N2-15q23, LSM16, YJDC, YJEFN2
Description	Enhancer of mRNA decapping 3 (HGNC Symbol)
Entrez gene summary	EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005 [PubMed 16364915]).[supplied by OMIM, Mar 2008]
Chromosome	15
Cytoband	q24.1
Chromosome location (bp)	74630558 - 74696292
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179151 (version 83.38)
Entrez gene	80153
UniProt	Q96F86 (UniProt - Evidence at protein level)
neXtProt	NX_Q96F86
Antibodypedia	EDC3 antibodies

PROTEIN BROWSER

EDC3-001	EDC3-003	EDC3-004	EDC3-005	EDC3-007	EDC3-009	EDC3-010	EDC3-012	EDC3-013	EDC3-014	EDC3-015	EDC3-016	EDC3-017	EDC3-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EDC3-001 ENSP00000320503 ENST00000315127	Q96F86 [Direct mapping] Enhancer of mRNA-decapping protein 3 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000932 [cytoplasmic mRNA processing body] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0042802 [identical protein binding] GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] GO:1990174 [phosphodiesterase decapping endonuclease activity] Show all	508 aa 56.1 kDa	No	0
EDC3-003 ENSP00000401343 ENST00000426797	Q96F86 [Direct mapping] Enhancer of mRNA-decapping protein 3 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000932 [cytoplasmic mRNA processing body] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0042802 [identical protein binding] GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] GO:1990174 [phosphodiesterase decapping endonuclease activity] Show all	508 aa 56.1 kDa	No	0
EDC3-004 ENSP00000455580 ENST00000568176	Q96F86 [Direct mapping] Enhancer of mRNA-decapping protein 3 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000932 [cytoplasmic mRNA processing body] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0042802 [identical protein binding] GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] GO:1990174 [phosphodiesterase decapping endonuclease activity] Show all	508 aa 56.1 kDa	No	0
EDC3-005 ENSP00000455393 ENST00000562174	H3BPN4 [Direct mapping] Enhancer of mRNA-decapping protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		213 aa 23.3 kDa	No	0
EDC3-007 ENSP00000457128 ENST00000562974	H3BTD6 [Direct mapping] Enhancer of mRNA-decapping protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		68 aa 7.8 kDa	No	0
EDC3-009 ENSP00000456805 ENST00000566219	H3BSQ0 [Direct mapping] Enhancer of mRNA-decapping protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		163 aa 18.5 kDa	No	0
EDC3-010 ENSP00000455589 ENST00000569561	H3BQ37 [Direct mapping] Enhancer of mRNA-decapping protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		178 aa 19.2 kDa	No	0
EDC3-012 ENSP00000455682 ENST00000566119	H3BQA1 [Direct mapping] Enhancer of mRNA-decapping protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		31 aa 3.2 kDa	No	0
EDC3-013 ENSP00000457170 ENST00000570138	H3BTH0 [Direct mapping] Enhancer of mRNA-decapping protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		101 aa 10.6 kDa	No	0
EDC3-014 ENSP00000454317 ENST00000563292	H3BMB8 [Direct mapping] Enhancer of mRNA-decapping protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		92 aa 9.8 kDa	No	0
EDC3-015 ENSP00000457156 ENST00000567813	H3BTF8 [Direct mapping] Enhancer of mRNA-decapping protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		54 aa 5.8 kDa	No	0
EDC3-016 ENSP00000455503 ENST00000563009	H3BPW9 [Direct mapping] Enhancer of mRNA-decapping protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		253 aa 28 kDa	No	0
EDC3-017 ENSP00000457523 ENST00000566243	H3BU87 [Direct mapping] Enhancer of mRNA-decapping protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		131 aa 13.8 kDa	No	0
EDC3-018 ENSP00000455870 ENST00000566828	H3BQP5 [Direct mapping] Enhancer of mRNA-decapping protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		123 aa 13 kDa	No	0

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