Expression of LDLRAD3 in cancer - Summary

GENERAL INFORMATION
Gene name	LDLRAD3
Gene description	Low density lipoprotein receptor class A domain containing 3
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in most tissues with cytoplasmic expression in selected tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA038251
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), lung cancer (unfavourable), urothelial cancer (unfavourable) and cervical cancer (unfavourable).
Renal cancer p<0.001 Lung cancer p<0.001 Urothelial cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA038251

GENE INFORMATION
Gene name	LDLRAD3 (HGNC Symbol)
Synonyms	LRAD3
Description	Low density lipoprotein receptor class A domain containing 3 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	p13
Chromosome location (bp)	35943981 - 36232136
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179241 (version 83.38)
Entrez gene	143458
UniProt	Q86YD5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q86YD5
Antibodypedia	LDLRAD3 antibodies

PROTEIN BROWSER

LDLRAD3-001	LDLRAD3-002	LDLRAD3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LDLRAD3-001 ENSP00000318607 ENST00000315571	Q86YD5 [Direct mapping] Low-density lipoprotein receptor class A domain-containing protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0070613 [regulation of protein processing] Show all	345 aa 37.4 kDa	Yes	1
LDLRAD3-002 ENSP00000433954 ENST00000528989	Q86YD5 [Direct mapping] Low-density lipoprotein receptor class A domain-containing protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] Show all	296 aa 32 kDa	Yes	1
LDLRAD3-003 ENSP00000434313 ENST00000524419	E9PR86 [Direct mapping] Low-density lipoprotein receptor class A domain-containing protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] Show all	335 aa 36 kDa	Yes	1