Expression of CLK3 in cancer - Summary - The Human Protein Atlas

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CLK3

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CLK3
Gene description	CDC-like kinase 3
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA046817
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable) and prostate cancer (unfavourable).
Colorectal cancer p<0.001 Prostate cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046817

GENE INFORMATION
Gene name	CLK3 (HGNC Symbol)
Synonyms	clk3
Description	CDC-like kinase 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q24.1
Chromosome location (bp)	74598500 - 74645414
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179335 (version 83.38)
Entrez gene	1198
UniProt	P49761 (UniProt - Evidence at protein level)
neXtProt	NX_P49761
Antibodypedia	CLK3 antibodies

PROTEIN BROWSER

CLK3-001	CLK3-003	CLK3-009	CLK3-010	CLK3-013	CLK3-014	CLK3-015	CLK3-016	CLK3-019	CLK3-023	CLK3-024	CLK3-027

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLK3-001 ENSP00000344112 ENST00000345005	P49761 [Direct mapping] Dual specificity protein kinase CLK3 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001669 [acrosomal vesicle] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006468 [protein phosphorylation] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0043484 [regulation of RNA splicing] GO:0044822 [poly(A) RNA binding] GO:0045111 [intermediate filament cytoskeleton] Show all	490 aa 58.6 kDa	No	0
CLK3-003 ENSP00000378505 ENST00000395066	P49761 [Direct mapping] Dual specificity protein kinase CLK3 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001669 [acrosomal vesicle] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006468 [protein phosphorylation] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016607 [nuclear speck] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0043484 [regulation of RNA splicing] GO:0044822 [poly(A) RNA binding] GO:0045111 [intermediate filament cytoskeleton] GO:0046777 [protein autophosphorylation] Show all	638 aa 73.5 kDa	No	0
CLK3-009 ENSP00000456399 ENST00000562389	H3BRT8 [Direct mapping] Dual-specificity protein kinase CLK3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		117 aa 15 kDa	No	0
CLK3-010 ENSP00000457696 ENST00000566126	H3BUL5 [Direct mapping] Dual-specificity protein kinase CLK3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006468 [protein phosphorylation] GO:0045111 [intermediate filament cytoskeleton] Show all	224 aa 27 kDa	No	0
CLK3-013 ENSP00000455762 ENST00000568139	H3BQG1 [Direct mapping] Dual-specificity protein kinase CLK3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006468 [protein phosphorylation] GO:0045111 [intermediate filament cytoskeleton] Show all	306 aa 36.4 kDa	No	0
CLK3-014 ENSP00000455905 ENST00000562670	H3BQR7 [Direct mapping] Dual-specificity protein kinase CLK3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		145 aa 18.2 kDa	No	0
CLK3-015 ENSP00000458099 ENST00000564096	H3BVF8 [Direct mapping] Dual-specificity protein kinase CLK3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006468 [protein phosphorylation] GO:0045111 [intermediate filament cytoskeleton] Show all	239 aa 28.9 kDa	No	0
CLK3-016 ENSP00000457362 ENST00000563297	H3BTW9 [Direct mapping] Dual-specificity protein kinase CLK3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		19 aa 2.3 kDa	No	0
CLK3-019 ENSP00000456202 ENST00000563842	H3BRE4 [Direct mapping] Dual-specificity protein kinase CLK3 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	190 aa 22.6 kDa	No	0
CLK3-023 ENSP00000454961 ENST00000566926	H3BNQ5 [Direct mapping] Dual-specificity protein kinase CLK3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	193 aa 22.4 kDa	No	0
CLK3-024 ENSP00000456431 ENST00000563418	H3BRW2 [Direct mapping] Dual-specificity protein kinase CLK3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		70 aa 8.2 kDa	No	0
CLK3-027 ENSP00000457936 ENST00000568488	H3BV35 [Direct mapping] Dual-specificity protein kinase CLK3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		160 aa 19.2 kDa	No	0

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