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GATA2

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GENERAL INFORMATION

Gene name

 GATA2

Gene description

 GATA binding protein 2

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Cell line enhanced (SH-SY5Y, HEL, BEWO, HMC-1)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA005633
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y, HEL, BEWO, HMC-1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA005633 A-431 Nucleoplasm
HPA005633 U-2 OS Nucleoplasm
HPA005633 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 GATA2 (HGNC Symbol)

Synonyms

 NFE1B

Description

 GATA binding protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Chromosome

 3

Cytoband

 q21.3

Chromosome location (bp)

 128479427 - 128493185

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179348 (version 83.38)

Entrez gene

 2624

UniProt

 P23769 (UniProt - Evidence at protein level)

neXtProt

 NX_P23769

Antibodypedia

 GATA2 antibodies

PROTEIN BROWSER
GATA2-001
GATA2-002
GATA2-003
GATA2-006
GATA2-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GATA2-001
ENSP00000345681
ENST00000341105
P23769 [Direct mapping]
Endothelial transcription factor GATA-2
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001655 [urogenital system development]
GO:0001709 [cell fate determination]
GO:0001764 [neuron migration]
GO:0001892 [embryonic placenta development]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006909 [phagocytosis]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007507 [heart development]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0009888 [tissue development]
GO:0021514 [ventral spinal cord interneuron differentiation]
GO:0021533 [cell differentiation in hindbrain]
GO:0021902 [commitment of neuronal cell to specific neuron type in forebrain]
GO:0021954 [central nervous system neuron development]
GO:0021983 [pituitary gland development]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0033993 [response to lipid]
GO:0035019 [somatic stem cell population maintenance]
GO:0035065 [regulation of histone acetylation]
GO:0035854 [eosinophil fate commitment]
GO:0042472 [inner ear morphogenesis]
GO:0042629 [mast cell granule]
GO:0043234 [protein complex]
GO:0043303 [mast cell degranulation]
GO:0043565 [sequence-specific DNA binding]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045650 [negative regulation of macrophage differentiation]
GO:0045654 [positive regulation of megakaryocyte differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045746 [negative regulation of Notch signaling pathway]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048469 [cell maturation]
GO:0048565 [digestive tract development]
GO:0048663 [neuron fate commitment]
GO:0048873 [homeostasis of number of cells within a tissue]
GO:0050766 [positive regulation of phagocytosis]
GO:0060100 [positive regulation of phagocytosis, engulfment]
GO:0060216 [definitive hemopoiesis]
GO:0060872 [semicircular canal development]
GO:0070345 [negative regulation of fat cell proliferation]
GO:0070742 [C2H2 zinc finger domain binding]
GO:0097154 [GABAergic neuron differentiation]
GO:2000178 [negative regulation of neural precursor cell proliferation]
GO:2000977 [regulation of forebrain neuron differentiation]
Show all
 480 aa
50.5 kDa 		No 0
GATA2-002
ENSP00000417074
ENST00000487848
P23769 [Direct mapping]
Endothelial transcription factor GATA-2
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006909 [phagocytosis]
GO:0007507 [heart development]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0009888 [tissue development]
GO:0035854 [eosinophil fate commitment]
GO:0043565 [sequence-specific DNA binding]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045746 [negative regulation of Notch signaling pathway]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048565 [digestive tract development]
GO:0050766 [positive regulation of phagocytosis]
GO:0070345 [negative regulation of fat cell proliferation]
GO:0070742 [C2H2 zinc finger domain binding]
GO:2000178 [negative regulation of neural precursor cell proliferation]
Show all
 480 aa
50.5 kDa 		No 0
GATA2-003
ENSP00000400259
ENST00000430265
P23769 [Direct mapping]
Endothelial transcription factor GATA-2
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006909 [phagocytosis]
GO:0007507 [heart development]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0009888 [tissue development]
GO:0035854 [eosinophil fate commitment]
GO:0043565 [sequence-specific DNA binding]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045746 [negative regulation of Notch signaling pathway]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048565 [digestive tract development]
GO:0050766 [positive regulation of phagocytosis]
GO:0070345 [negative regulation of fat cell proliferation]
GO:0070742 [C2H2 zinc finger domain binding]
GO:2000178 [negative regulation of neural precursor cell proliferation]
Show all
 466 aa
49.1 kDa 		No 0
GATA2-006
ENSP00000419532
ENST00000498200
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Show all
 8 aa
0.9 kDa 		No 0
GATA2-007
ENSP00000418132
ENST00000492608
C9J965 [Direct mapping]
Endothelial transcription factor GATA-2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030097 [hemopoiesis]
Show all
 150 aa
15.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.