Expression of GEMIN4 in cancer - Summary - The Human Protein Atlas

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GEMIN4

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GEMIN4
Gene description	Gem (nuclear organelle) associated protein 4
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA067891
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA067891

GENE INFORMATION
Gene name	GEMIN4 (HGNC Symbol)
Synonyms	DKFZP434B131, DKFZP434D174, HC56, HCAP1, HHRF-1, p97
Description	Gem (nuclear organelle) associated protein 4 (HGNC Symbol)
Entrez gene summary	The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p13.3
Chromosome location (bp)	744414 - 753999
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179409 (version 83.38)
Entrez gene	50628
UniProt	P57678 (UniProt - Evidence at protein level)
neXtProt	NX_P57678
Antibodypedia	GEMIN4 antibodies

PROTEIN BROWSER

GEMIN4-001	GEMIN4-002	GEMIN4-003	GEMIN4-004	GEMIN4-005	GEMIN4-006	GEMIN4-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GEMIN4-001 ENSP00000321706 ENST00000319004	P57678 [Direct mapping] Gem-associated protein 4 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000387 [spliceosomal snRNP assembly] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006364 [rRNA processing] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0030532 [small nuclear ribonucleoprotein complex] GO:0032797 [SMN complex] GO:0034660 [ncRNA metabolic process] GO:0034719 [SMN-Sm protein complex] GO:0070062 [extracellular exosome] GO:0097504 [Gemini of coiled bodies] Show all	1058 aa 120 kDa	No	0
GEMIN4-002 ENSP00000459565 ENST00000576778	I3L2C7 [Direct mapping] Gem-associated protein 4 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		1047 aa 118.8 kDa	No	0
GEMIN4-003 ENSP00000392460 ENST00000437269	E7EN12 [Direct mapping] Gem-associated protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		184 aa 21.1 kDa	No	0
GEMIN4-004 ENSP00000461368 ENST00000576383	I3L4M4 [Direct mapping] Gem-associated protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		189 aa 21.5 kDa	No	0
GEMIN4-005 ENSP00000461103 ENST00000570364	I3L4A4 [Direct mapping] Gem-associated protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		271 aa 30.4 kDa	No	0
GEMIN4-006 ENSP00000458896 ENST00000574958	I3L1J7 [Direct mapping] Gem-associated protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		70 aa 7.8 kDa	No	0
GEMIN4-007 ENSP00000460286 ENST00000573482	I3L399 [Direct mapping] Gem-associated protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		296 aa 33.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.