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ALOX15B

GENERAL INFORMATION

Gene name

 ALOX15B

Gene description

 Arachidonate 15-lipoxygenase, type B

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (breast, prostate)
GTEx:Tissue enhanced (prostate)
FANTOM5:Tissue enhanced (esophagus, lung)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (breast, prostate)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (prostate)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, lung)

GENE INFORMATION

Gene name

 ALOX15B (HGNC Symbol)

Synonyms

 15-LOX-2

Description

 Arachidonate 15-lipoxygenase, type B (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 8039017 - 8049134

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179593 (version 83.38)

Entrez gene

 247

UniProt

 O15296 (UniProt - Evidence at protein level)

neXtProt

 NX_O15296

Antibodypedia

 ALOX15B antibodies

PROTEIN BROWSER
ALOX15B-001
ALOX15B-002
ALOX15B-005
ALOX15B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALOX15B-001
ENSP00000369530
ENST00000380183
O15296 [Direct mapping]
Arachidonate 15-lipoxygenase B
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006915 [apoptotic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0016020 [membrane]
GO:0016165 [linoleate 13S-lipoxygenase activity]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0019369 [arachidonic acid metabolic process]
GO:0019372 [lipoxygenase pathway]
GO:0019898 [extrinsic component of membrane]
GO:0030336 [negative regulation of cell migration]
GO:0030850 [prostate gland development]
GO:0030856 [regulation of epithelial cell differentiation]
GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0036403 [arachidonate 8(S)-lipoxygenase activity]
GO:0043651 [linoleic acid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045618 [positive regulation of keratinocyte differentiation]
GO:0045786 [negative regulation of cell cycle]
GO:0045926 [negative regulation of growth]
GO:0046872 [metal ion binding]
GO:0050473 [arachidonate 15-lipoxygenase activity]
GO:0051122 [hepoxilin biosynthetic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0090197 [positive regulation of chemokine secretion]
Show all
 676 aa
75.9 kDa 		No 0
ALOX15B-002
ENSP00000458749
ENST00000572022
I3L1D5 [Direct mapping]
Arachidonate 15-lipoxygenase B
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
Show all
 664 aa
74.5 kDa 		No 0
ALOX15B-005
ENSP00000460332
ENST00000573359
O15296 [Direct mapping]
Arachidonate 15-lipoxygenase B
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006915 [apoptotic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0016020 [membrane]
GO:0016165 [linoleate 13S-lipoxygenase activity]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0019369 [arachidonic acid metabolic process]
GO:0019372 [lipoxygenase pathway]
GO:0019898 [extrinsic component of membrane]
GO:0030336 [negative regulation of cell migration]
GO:0030850 [prostate gland development]
GO:0030856 [regulation of epithelial cell differentiation]
GO:0044281 [small molecule metabolic process]
GO:0045786 [negative regulation of cell cycle]
GO:0045926 [negative regulation of growth]
GO:0046872 [metal ion binding]
GO:0050473 [arachidonate 15-lipoxygenase activity]
GO:0051122 [hepoxilin biosynthetic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0090197 [positive regulation of chemokine secretion]
Show all
 602 aa
67.3 kDa 		No 0
ALOX15B-201
ENSP00000369520
ENST00000380173
O15296 [Direct mapping]
Arachidonate 15-lipoxygenase B
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006915 [apoptotic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0016020 [membrane]
GO:0016165 [linoleate 13S-lipoxygenase activity]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0019369 [arachidonic acid metabolic process]
GO:0019372 [lipoxygenase pathway]
GO:0019898 [extrinsic component of membrane]
GO:0030336 [negative regulation of cell migration]
GO:0030850 [prostate gland development]
GO:0030856 [regulation of epithelial cell differentiation]
GO:0044281 [small molecule metabolic process]
GO:0045786 [negative regulation of cell cycle]
GO:0045926 [negative regulation of growth]
GO:0046872 [metal ion binding]
GO:0050473 [arachidonate 15-lipoxygenase activity]
GO:0051122 [hepoxilin biosynthetic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0090197 [positive regulation of chemokine secretion]
Show all
 647 aa
72.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.