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CDC42EP4

GENERAL INFORMATION

Gene name

 CDC42EP4

Gene description

 CDC42 effector protein (Rho GTPase binding) 4

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA023335
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA023335

GENE INFORMATION

Gene name

 CDC42EP4 (HGNC Symbol)

Synonyms

 BORG4, CEP4, KAIA1777, MGC17125, MGC3740

Description

 CDC42 effector protein (Rho GTPase binding) 4 (HGNC Symbol)

Entrez gene summary

 The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q25.1

Chromosome location (bp)

 73283624 - 73312175

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179604 (version 83.38)

Entrez gene

 23580

UniProt

 Q9H3Q1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H3Q1

Antibodypedia

 CDC42EP4 antibodies

PROTEIN BROWSER
CDC42EP4-001
CDC42EP4-003
CDC42EP4-004
CDC42EP4-006
CDC42EP4-009
CDC42EP4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC42EP4-001
ENSP00000338258
ENST00000335793
Q9H3Q1 [Direct mapping]
Cdc42 effector protein 4
B2R6D8 [Target identity:100%; Query identity:100%]
CDC42 effector protein (Rho GTPase binding) 4, isoform CRA_a; cDNA FLJ14479 fis, clone MAMMA1002143, highly similar to Cdc42 effector protein 4 (Binder of Rho GTPases 4); cDNA, FLJ92905, Homo sapiens CDC42 effector protein (Rho GTPase binding) 4(CDC42EP4), mRNA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0012505 [endomembrane system]
GO:0015629 [actin cytoskeleton]
GO:0015630 [microtubule cytoskeleton]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0043547 [positive regulation of GTPase activity]
GO:0044822 [poly(A) RNA binding]
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 356 aa
38 kDa 		No 0
CDC42EP4-003
ENSP00000404270
ENST00000439510
Q9H3Q1 [Direct mapping]
Cdc42 effector protein 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0012505 [endomembrane system]
GO:0015629 [actin cytoskeleton]
GO:0015630 [microtubule cytoskeleton]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0043547 [positive regulation of GTPase activity]
GO:0044822 [poly(A) RNA binding]
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 286 aa
30.2 kDa 		No 0
CDC42EP4-004
ENSP00000463877
ENST00000579611
J3QQS6 [Direct mapping]
Cdc42 effector protein 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0043547 [positive regulation of GTPase activity]
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 73 aa
7.8 kDa 		No 0
CDC42EP4-006
ENSP00000462231
ENST00000580315
J3KRZ9 [Direct mapping]
Cdc42 effector protein 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0015629 [actin cytoskeleton]
GO:0015630 [microtubule cytoskeleton]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0043547 [positive regulation of GTPase activity]
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 127 aa
14 kDa 		No 0
CDC42EP4-009
ENSP00000464104
ENST00000581014
J3QR93 [Direct mapping]
Cdc42 effector protein 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0043547 [positive regulation of GTPase activity]
Show all
 79 aa
8.5 kDa 		No 0
CDC42EP4-201
ENSP00000485861
ENST00000630622
J3QR93 [Direct mapping]
Cdc42 effector protein 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0043547 [positive regulation of GTPase activity]
Show all
 79 aa
8.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.