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MAF1

GENERAL INFORMATION

Gene name

 MAF1

Gene description

 MAF1 homolog, negative regulator of RNA polymerase III

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA024821 , HPA058548
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024821
HPA058548

GENE INFORMATION

Gene name

 MAF1 (HGNC Symbol)

Synonyms

 DKFZp586G1123

Description

 MAF1 homolog, negative regulator of RNA polymerase III (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q24.3

Chromosome location (bp)

 144104499 - 144107611

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179632 (version 83.38)

Entrez gene

 84232

UniProt

 Q9H063 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H063

Antibodypedia

 MAF1 antibodies

PROTEIN BROWSER
MAF1-001
MAF1-002
MAF1-003
MAF1-004
MAF1-005
MAF1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAF1-001
ENSP00000318604
ENST00000322428
Q9H063 [Direct mapping]
Repressor of RNA polymerase III transcription MAF1 homolog
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000994 [RNA polymerase III core binding]
GO:0001030 [RNA polymerase III type 1 promoter DNA binding]
GO:0001031 [RNA polymerase III type 2 promoter DNA binding]
GO:0001032 [RNA polymerase III type 3 promoter DNA binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0016480 [negative regulation of transcription from RNA polymerase III promoter]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050811 [GABA receptor binding]
GO:0060077 [inhibitory synapse]
GO:0070217 [transcription factor TFIIIB complex assembly]
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 256 aa
28.8 kDa 		No 0
MAF1-002
ENSP00000433979
ENST00000534585
E9PSH4 [Direct mapping]
Repressor of RNA polymerase III transcription MAF1 homolog
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000994 [RNA polymerase III core binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0016480 [negative regulation of transcription from RNA polymerase III promoter]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0070217 [transcription factor TFIIIB complex assembly]
Show all
 286 aa
32 kDa 		No 0
MAF1-003
ENSP00000436720
ENST00000532522
Q9H063 [Direct mapping]
Repressor of RNA polymerase III transcription MAF1 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000994 [RNA polymerase III core binding]
GO:0001030 [RNA polymerase III type 1 promoter DNA binding]
GO:0001031 [RNA polymerase III type 2 promoter DNA binding]
GO:0001032 [RNA polymerase III type 3 promoter DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006351 [transcription, DNA-templated]
GO:0016480 [negative regulation of transcription from RNA polymerase III promoter]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0070217 [transcription factor TFIIIB complex assembly]
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 256 aa
28.8 kDa 		No 0
MAF1-004
ENSP00000431907
ENST00000527572
E9PJ05 [Direct mapping]
Repressor of RNA polymerase III transcription MAF1 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000994 [RNA polymerase III core binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0016480 [negative regulation of transcription from RNA polymerase III promoter]
GO:0070217 [transcription factor TFIIIB complex assembly]
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 70 aa
7.7 kDa 		No 0
MAF1-005
ENSP00000436030
ENST00000527058
E9PR76 [Direct mapping]
Repressor of RNA polymerase III transcription MAF1 homolog
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000994 [RNA polymerase III core binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0016480 [negative regulation of transcription from RNA polymerase III promoter]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0070217 [transcription factor TFIIIB complex assembly]
Show all
 252 aa
28.3 kDa 		No 0
MAF1-006
ENSP00000436639
ENST00000534811
H0YEV4 [Direct mapping]
Repressor of RNA polymerase III transcription MAF1 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000994 [RNA polymerase III core binding]
GO:0016480 [negative regulation of transcription from RNA polymerase III promoter]
GO:0070217 [transcription factor TFIIIB complex assembly]
Show all
 164 aa
18.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.