Cell atlas - FCER1A - The Human Protein Atlas

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FCER1A

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	FCER1A
Gene description	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
Protein class	FDA approved drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enriched (HEL)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	FCER1A (HGNC Symbol)
Synonyms	FCE1A
Description	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide (HGNC Symbol)
Entrez gene summary	The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
Chromosome	1
Cytoband	q23.2
Chromosome location (bp)	159289714 - 159308224
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179639 (version 83.38)
Entrez gene	2205
UniProt	P12319 (UniProt - Evidence at protein level)
neXtProt	NX_P12319
Antibodypedia	FCER1A antibodies

PROTEIN BROWSER

FCER1A-001	FCER1A-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FCER1A-001 ENSP00000357097 ENST00000368115	P12319 [Direct mapping] High affinity immunoglobulin epsilon receptor subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Small molecule drugs Show all	GO:0000187 [activation of MAPK activity] GO:0001812 [positive regulation of type I hypersensitivity] GO:0001820 [serotonin secretion] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007257 [activation of JUN kinase activity] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0019370 [leukotriene biosynthetic process] GO:0019767 [IgE receptor activity] GO:0019863 [IgE binding] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043306 [positive regulation of mast cell degranulation] GO:0045087 [innate immune response] GO:0045401 [positive regulation of interleukin-3 biosynthetic process] GO:0045425 [positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050850 [positive regulation of calcium-mediated signaling] Show all	257 aa 29.6 kDa	Yes	1
FCER1A-002 ENSP00000357096 ENST00000368114	E9PRN1 [Direct mapping] High affinity immunoglobulin epsilon receptor subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	224 aa 25.8 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.