Expression of PCED1B in cancer - Summary

GENERAL INFORMATION
Gene name	PCED1B
Gene description	PC-esterase domain containing 1B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (A549, K-562)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several different tissues, distinct expression in monocyte-derived cell types.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. HPA043901
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA043901

GENE INFORMATION
Gene name	PCED1B (HGNC Symbol)
Synonyms	FAM113B, MGC16044
Description	PC-esterase domain containing 1B (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the GDSL/SGNH-like acyl-esterase family. Members of this family are hydrolases thought to function in modification of biopolymers on the cell surface. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Chromosome	12
Cytoband	q13.11
Chromosome location (bp)	47079603 - 47236662
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179715 (version 83.38)
Entrez gene	91523
UniProt	Q96HM7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96HM7
Antibodypedia	PCED1B antibodies

PROTEIN BROWSER

PCED1B-001	PCED1B-003	PCED1B-004	PCED1B-005	PCED1B-006	PCED1B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCED1B-001 ENSP00000446688 ENST00000546455	Q96HM7 [Direct mapping] PC-esterase domain-containing protein 1B A0A024R115 [Target identity:100%; Query identity:100%] Family with sequence similarity 113, member B, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	432 aa 49.7 kDa	No	0
PCED1B-003 ENSP00000448693 ENST00000548348	F8VRF7 [Direct mapping] PC-esterase domain-containing protein 1B Show all	Predicted intracellular proteins Show all		189 aa 21.7 kDa	No	0
PCED1B-004 ENSP00000449680 ENST00000549500	A0A0E3D6L9 [Direct mapping] PC-esterase domain-containing protein 1B Show all	Predicted intracellular proteins Show all		167 aa 19.6 kDa	No	0
PCED1B-005 ENSP00000448000 ENST00000549630	F8VUD2 [Direct mapping] PC-esterase domain-containing protein 1B Show all	Predicted intracellular proteins Show all		168 aa 19.7 kDa	No	0
PCED1B-006 ENSP00000448926 ENST00000551777	F8VYL8 [Direct mapping] PC-esterase domain-containing protein 1B Show all	Predicted intracellular proteins Show all		58 aa 6.7 kDa	No	0
PCED1B-201 ENSP00000396040 ENST00000432328	Q96HM7 [Direct mapping] PC-esterase domain-containing protein 1B A0A024R115 [Target identity:100%; Query identity:100%] Family with sequence similarity 113, member B, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	432 aa 49.7 kDa	No	0