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ATOH7

GENERAL INFORMATION

Gene name

 ATOH7

Gene description

 Atonal bHLH transcription factor 7

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Tissue enhanced (cerebellum)
FANTOM5:Tissue enhanced (cerebellum, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA027008
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, hippocampus)

GENE INFORMATION

Gene name

 ATOH7 (HGNC Symbol)

Synonyms

 bHLHa13, Math5

Description

 Atonal bHLH transcription factor 7 (HGNC Symbol)

Entrez gene summary

 This intronless gene encodes a member of the basic helix-loop-helix family of transcription factors, with similarity to Drosophila atonal gene that controls photoreceptor development. Studies in mice suggest that this gene plays a central role in retinal ganglion cell and optic nerve formation. Mutations in this gene are associated with nonsyndromic congenital retinal nonattachment. [provided by RefSeq, Dec 2011]

Chromosome

 10

Cytoband

 q21.3

Chromosome location (bp)

 68230624 - 68232103

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179774 (version 83.38)

Entrez gene

 220202

UniProt

 Q8N100 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N100

Antibodypedia

 ATOH7 antibodies

PROTEIN BROWSER
ATOH7-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATOH7-001
ENSP00000362777
ENST00000373673
Q8N100 [Direct mapping]
Protein atonal homolog 7
F1T0H4 [Target identity:100%; Query identity:100%]
HCG1795924; Protein atonal homolog 7
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Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Show all
GO:0003407 [neural retina development]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007623 [circadian rhythm]
GO:0009649 [entrainment of circadian clock]
GO:0021554 [optic nerve development]
GO:0030154 [cell differentiation]
GO:0046983 [protein dimerization activity]
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 152 aa
16.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.