Expression of CDH5 in cancer - Summary - The Human Protein Atlas

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CDH5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CDH5
Gene description	Cadherin 5, type 2 (vascular endothelium)
Protein class	Cancer-related genes CD markers Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (HUVEC TERT2, TIME)
HPA (normal tissue):	Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. CAB028366
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB028366

GENE INFORMATION
Gene name	CDH5 (HGNC Symbol)
Synonyms	7B4, CD144
Description	Cadherin 5, type 2 (vascular endothelium) (HGNC Symbol)
Entrez gene summary	This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015]
Chromosome	16
Cytoband	q21
Chromosome location (bp)	66366622 - 66404786
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179776 (version 83.38)
Entrez gene	1003
UniProt	P33151 (UniProt - Evidence at protein level)
neXtProt	NX_P33151
Antibodypedia	CDH5 antibodies

PROTEIN BROWSER

CDH5-001	CDH5-002	CDH5-003	CDH5-004	CDH5-005	CDH5-007	CDH5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDH5-001 ENSP00000344115 ENST00000341529	P33151 [Direct mapping] Cadherin-5 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001955 [blood vessel maturation] GO:0005102 [receptor binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005912 [adherens junction] GO:0005923 [bicellular tight junction] GO:0007043 [cell-cell junction assembly] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008013 [beta-catenin binding] GO:0008285 [negative regulation of cell proliferation] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019903 [protein phosphatase binding] GO:0030054 [cell junction] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0044325 [ion channel binding] GO:0045216 [cell-cell junction organization] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0071944 [cell periphery] GO:1903142 [positive regulation of establishment of endothelial barrier] GO:2000114 [regulation of establishment of cell polarity] Show all	784 aa 87.5 kDa	Yes	1
CDH5-002 ENSP00000461880 ENST00000539168	B4DTR2 [Direct mapping] Cadherin-5; cDNA FLJ51088, highly similar to Cadherin-5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001955 [blood vessel maturation] GO:0005509 [calcium ion binding] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	223 aa 24.3 kDa	No	1
CDH5-003 ENSP00000455655 ENST00000568023	H3BQ82 [Direct mapping] Cadherin-5 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		17 aa 1.8 kDa	No	0
CDH5-004 ENSP00000456093 ENST00000568155	H3BR64 [Direct mapping] Cadherin-5 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001955 [blood vessel maturation] GO:0005509 [calcium ion binding] GO:0007155 [cell adhesion] Show all	76 aa 8.4 kDa	Yes	0
CDH5-005 ENSP00000455302 ENST00000562048	H3BPG1 [Direct mapping] Cadherin-5 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001955 [blood vessel maturation] GO:0005509 [calcium ion binding] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] Show all	131 aa 14.6 kDa	Yes	0
CDH5-007 ENSP00000458878 ENST00000563425	I3L1J2 [Direct mapping] Cadherin-5 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	406 aa 45.4 kDa	Yes	0
CDH5-201 ENSP00000479381 ENST00000614547	P33151 [Direct mapping] Cadherin-5 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0007043 [cell-cell junction assembly] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008013 [beta-catenin binding] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0044325 [ion channel binding] GO:0045216 [cell-cell junction organization] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:1903142 [positive regulation of establishment of endothelial barrier] GO:2000114 [regulation of establishment of cell polarity] Show all	669 aa 74.5 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.