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AKAP5

GENERAL INFORMATION

Gene name

 AKAP5

Gene description

 A kinase (PRKA) anchor protein 5

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (CACO-2)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA053891 , CAB004308
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA053891
CAB004308

GENE INFORMATION

Gene name

 AKAP5 (HGNC Symbol)

Synonyms

 AKAP75, AKAP79

Description

 A kinase (PRKA) anchor protein 5 (HGNC Symbol)

Entrez gene summary

 The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q23.3

Chromosome location (bp)

 64465499 - 64474503

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179841 (version 83.38)

Entrez gene

 9495

UniProt

 P24588 (UniProt - Evidence at protein level)

neXtProt

 NX_P24588

Antibodypedia

 AKAP5 antibodies

PROTEIN BROWSER
AKAP5-001
AKAP5-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKAP5-001
ENSP00000315615
ENST00000320636
P24588 [Direct mapping]
A-kinase anchor protein 5
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006605 [protein targeting]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0008179 [adenylate cyclase binding]
GO:0010739 [positive regulation of protein kinase A signaling]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0034237 [protein kinase A regulatory subunit binding]
GO:0044281 [small molecule metabolic process]
GO:0050796 [regulation of insulin secretion]
GO:0051018 [protein kinase A binding]
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 427 aa
47.1 kDa 		No 0
AKAP5-002
ENSP00000378207
ENST00000394718
P24588 [Direct mapping]
A-kinase anchor protein 5
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001664 [G-protein coupled receptor binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006605 [protein targeting]
GO:0007165 [signal transduction]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007268 [synaptic transmission]
GO:0008179 [adenylate cyclase binding]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010739 [positive regulation of protein kinase A signaling]
GO:0014069 [postsynaptic density]
GO:0014850 [response to muscle activity]
GO:0016323 [basolateral plasma membrane]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0021510 [spinal cord development]
GO:0021766 [hippocampus development]
GO:0030346 [protein phosphatase 2B binding]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031527 [filopodium membrane]
GO:0032279 [asymmetric synapse]
GO:0032403 [protein complex binding]
GO:0032590 [dendrite membrane]
GO:0032591 [dendritic spine membrane]
GO:0034237 [protein kinase A regulatory subunit binding]
GO:0036394 [amylase secretion]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0043234 [protein complex]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043271 [negative regulation of ion transport]
GO:0043624 [cellular protein complex disassembly]
GO:0044281 [small molecule metabolic process]
GO:0045296 [cadherin binding]
GO:0045762 [positive regulation of adenylate cyclase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050775 [positive regulation of dendrite morphogenesis]
GO:0050796 [regulation of insulin secretion]
GO:0050811 [GABA receptor binding]
GO:0051018 [protein kinase A binding]
GO:0051533 [positive regulation of NFAT protein import into nucleus]
GO:0051602 [response to electrical stimulus]
GO:0060135 [maternal process involved in female pregnancy]
GO:0071417 [cellular response to organonitrogen compound]
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 427 aa
47.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.