We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Few squamous cell carcinomas, renal cell carcinomas, pancreatic and urothelial cancers showed moderate cytoplasmic and/or membranous positivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
CITED4
Synonyms
Description
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 (HGNC Symbol)
Entrez gene summary
The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011]