Expression of DCTPP1 in cancer - Summary

GENERAL INFORMATION
Gene name	DCTPP1
Gene description	DCTP pyrophosphatase 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues, including most glandular and squamous epithelial cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA002832
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), breast cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Breast cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA002832

GENE INFORMATION
Gene name	DCTPP1 (HGNC Symbol)
Synonyms	CDA03, MGC5627, RS21C6, XTP3TPA
Description	DCTP pyrophosphatase 1 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	30423619 - 30430075
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179958 (version 83.38)
Entrez gene	79077
UniProt	Q9H773 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H773
Antibodypedia	DCTPP1 antibodies

PROTEIN BROWSER

DCTPP1-001	DCTPP1-002	DCTPP1-003	DCTPP1-004	DCTPP1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DCTPP1-001 ENSP00000322524 ENST00000319285	Q9H773 [Direct mapping] dCTP pyrophosphatase 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0009143 [nucleoside triphosphate catabolic process] GO:0016462 [pyrophosphatase activity] GO:0032556 [pyrimidine deoxyribonucleotide binding] GO:0042802 [identical protein binding] GO:0047429 [nucleoside-triphosphate diphosphatase activity] GO:0047840 [dCTP diphosphatase activity] GO:0051289 [protein homotetramerization] Show all	170 aa 18.7 kDa	No	0
DCTPP1-002 ENSP00000456612 ENST00000567983	H3BSA6 [Direct mapping] dCTP pyrophosphatase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		71 aa 7.7 kDa	No	0
DCTPP1-003 ENSP00000460933 ENST00000565758	H3BPN2 [Direct mapping] dCTP pyrophosphatase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		49 aa 5.4 kDa	No	0
DCTPP1-004 ENSP00000460764 ENST00000568973	H3BPN2 [Direct mapping] dCTP pyrophosphatase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		49 aa 5.4 kDa	No	0
DCTPP1-005 ENSP00000455391 ENST00000568434	H3BPN2 [Direct mapping] dCTP pyrophosphatase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		49 aa 5.4 kDa	No	0