Expression of ZADH2 in cancer - Summary - The Human Protein Atlas

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ZADH2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZADH2
Gene description	Zinc binding alcohol dehydrogenase domain containing 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA021468
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and thyroid cancer (unfavourable).
Renal cancer p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021468

GENE INFORMATION
Gene name	ZADH2 (HGNC Symbol)
Synonyms	MGC45594
Description	Zinc binding alcohol dehydrogenase domain containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	18
Cytoband	q22.3
Chromosome location (bp)	75195108 - 75209348
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180011 (version 83.38)
Entrez gene	284273
UniProt	Q8N4Q0 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N4Q0
Antibodypedia	ZADH2 antibodies

PROTEIN BROWSER

ZADH2-001	ZADH2-002	ZADH2-003	ZADH2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZADH2-001 ENSP00000323678 ENST00000322342	Q8N4Q0 [Direct mapping] Zinc-binding alcohol dehydrogenase domain-containing protein 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005739 [mitochondrion] GO:0005777 [peroxisome] GO:0008150 [biological_process] GO:0008270 [zinc ion binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	377 aa 40.1 kDa	No	0
ZADH2-002 ENSP00000440111 ENST00000537114	Q8N4Q0 [Direct mapping] Zinc-binding alcohol dehydrogenase domain-containing protein 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005777 [peroxisome] GO:0008150 [biological_process] GO:0008270 [zinc ion binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	254 aa 26.9 kDa	No	0
ZADH2-003 ENSP00000463106 ENST00000582437	J3KTQ8 [Direct mapping] Zinc-binding alcohol dehydrogenase domain-containing protein 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	155 aa 16.2 kDa	No	0
ZADH2-004 ENSP00000463844 ENST00000581620	J3QQQ7 [Direct mapping] Zinc-binding alcohol dehydrogenase domain-containing protein 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	101 aa 10.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.