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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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TH
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

TH

Gene description

Tyrosine hydroxylase

Protein class

Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enhanced (urothelial cancer)
HPA (cell line):Group enriched (PC-3, SK-BR-3)
HPA (normal tissue):Tissue enriched (adrenal gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in adrenal medulla, peripheral nerve fibers and caudate nucleus.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA061003 , CAB002522 , CAB072340
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enhanced (urothelial cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA061003
CAB002522
CAB072340

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

All cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

All cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few cases of seminomas along with rare thyroid and colorectal cancers showed moderate nuclear positivity. Subset tumor cells in ovarian cancer showed strong nuclear positivity. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

TH (HGNC Symbol)

Synonyms

DYT5b

Description

Tyrosine hydroxylase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p15.5

Chromosome location (bp)

2163929 - 2171877

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000180176 (version 83.38)

Entrez gene

7054

UniProt

P07101 (UniProt - Evidence at protein level)

neXtProt

NX_P07101

Antibodypedia

TH antibodies

PROTEIN BROWSER

TH-001
TH-002
TH-003
TH-005
TH-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TH-001
ENSP00000325951
ENST00000352909
P07101 [Direct mapping]
Tyrosine 3-monooxygenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0003007 [heart morphogenesis]
GO:0004497 [monooxygenase activity]
GO:0004511 [tyrosine 3-monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006585 [dopamine biosynthetic process from tyrosine]
GO:0007507 [heart development]
GO:0007601 [visual perception]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0007626 [locomotory behavior]
GO:0008016 [regulation of heart contraction]
GO:0009072 [aromatic amino acid family metabolic process]
GO:0009653 [anatomical structure morphogenesis]
GO:0009887 [organ morphogenesis]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0016714 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen]
GO:0019899 [enzyme binding]
GO:0031410 [cytoplasmic vesicle]
GO:0033162 [melanosome membrane]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042416 [dopamine biosynthetic process]
GO:0042418 [epinephrine biosynthetic process]
GO:0042421 [norepinephrine biosynthetic process]
GO:0042423 [catecholamine biosynthetic process]
GO:0042462 [eye photoreceptor cell development]
GO:0043005 [neuron projection]
GO:0043204 [perikaryon]
GO:0043473 [pigmentation]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0048596 [embryonic camera-type eye morphogenesis]
GO:0055114 [oxidation-reduction process]
Show all
497 aa
55.6 kDa
No 0
TH-002
ENSP00000370571
ENST00000381178
P07101 [Direct mapping]
Tyrosine 3-monooxygenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0001975 [response to amphetamine]
GO:0003007 [heart morphogenesis]
GO:0004497 [monooxygenase activity]
GO:0004511 [tyrosine 3-monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006585 [dopamine biosynthetic process from tyrosine]
GO:0006631 [fatty acid metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0007507 [heart development]
GO:0007601 [visual perception]
GO:0007605 [sensory perception of sound]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0007617 [mating behavior]
GO:0007626 [locomotory behavior]
GO:0008016 [regulation of heart contraction]
GO:0008021 [synaptic vesicle]
GO:0008198 [ferrous iron binding]
GO:0008199 [ferric iron binding]
GO:0009072 [aromatic amino acid family metabolic process]
GO:0009414 [response to water deprivation]
GO:0009416 [response to light stimulus]
GO:0009635 [response to herbicide]
GO:0009651 [response to salt stress]
GO:0009653 [anatomical structure morphogenesis]
GO:0009887 [organ morphogenesis]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010038 [response to metal ion]
GO:0010043 [response to zinc ion]
GO:0010259 [multicellular organismal aging]
GO:0014070 [response to organic cyclic compound]
GO:0014823 [response to activity]
GO:0015842 [synaptic vesicle amine transport]
GO:0016137 [glycoside metabolic process]
GO:0016597 [amino acid binding]
GO:0016714 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen]
GO:0017085 [response to insecticide]
GO:0018963 [phthalate metabolic process]
GO:0019825 [oxygen binding]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0021987 [cerebral cortex development]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0031667 [response to nutrient levels]
GO:0032355 [response to estradiol]
GO:0032496 [response to lipopolysaccharide]
GO:0033076 [isoquinoline alkaloid metabolic process]
GO:0033162 [melanosome membrane]
GO:0034617 [tetrahydrobiopterin binding]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035094 [response to nicotine]
GO:0035176 [social behavior]
GO:0035240 [dopamine binding]
GO:0035690 [cellular response to drug]
GO:0035900 [response to isolation stress]
GO:0035902 [response to immobilization stress]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042214 [terpene metabolic process]
GO:0042416 [dopamine biosynthetic process]
GO:0042418 [epinephrine biosynthetic process]
GO:0042421 [norepinephrine biosynthetic process]
GO:0042423 [catecholamine biosynthetic process]
GO:0042462 [eye photoreceptor cell development]
GO:0042493 [response to drug]
GO:0042745 [circadian sleep/wake cycle]
GO:0042755 [eating behavior]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043195 [terminal bouton]
GO:0043204 [perikaryon]
GO:0043434 [response to peptide hormone]
GO:0043473 [pigmentation]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0045472 [response to ether]
GO:0046684 [response to pyrethroid]
GO:0048545 [response to steroid hormone]
GO:0048596 [embryonic camera-type eye morphogenesis]
GO:0050890 [cognition]
GO:0051412 [response to corticosterone]
GO:0051602 [response to electrical stimulus]
GO:0052314 [phytoalexin metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070848 [response to growth factor]
GO:0071287 [cellular response to manganese ion]
GO:0071312 [cellular response to alkaloid]
GO:0071316 [cellular response to nicotine]
GO:0071333 [cellular response to glucose stimulus]
GO:0071363 [cellular response to growth factor stimulus]
Show all
528 aa
58.6 kDa
No 0
TH-003
ENSP00000370567
ENST00000381175
P07101 [Direct mapping]
Tyrosine 3-monooxygenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0003007 [heart morphogenesis]
GO:0004497 [monooxygenase activity]
GO:0004511 [tyrosine 3-monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006585 [dopamine biosynthetic process from tyrosine]
GO:0007507 [heart development]
GO:0007601 [visual perception]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0007626 [locomotory behavior]
GO:0008016 [regulation of heart contraction]
GO:0009072 [aromatic amino acid family metabolic process]
GO:0009653 [anatomical structure morphogenesis]
GO:0009887 [organ morphogenesis]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0016714 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen]
GO:0019899 [enzyme binding]
GO:0031410 [cytoplasmic vesicle]
GO:0033162 [melanosome membrane]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042416 [dopamine biosynthetic process]
GO:0042418 [epinephrine biosynthetic process]
GO:0042421 [norepinephrine biosynthetic process]
GO:0042423 [catecholamine biosynthetic process]
GO:0042462 [eye photoreceptor cell development]
GO:0043005 [neuron projection]
GO:0043204 [perikaryon]
GO:0043473 [pigmentation]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0048596 [embryonic camera-type eye morphogenesis]
GO:0055114 [oxidation-reduction process]
Show all
524 aa
58.2 kDa
No 0
TH-005
ENSP00000403546
ENST00000412076
H0Y677 [Direct mapping]
Tyrosine 3-monooxygenase
Show all
Predicted intracellular proteins
Show all
GO:0005506 [iron ion binding]
GO:0009072 [aromatic amino acid family metabolic process]
GO:0016714 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen]
GO:0055114 [oxidation-reduction process]
Show all
116 aa
13 kDa
No 0
TH-201
ENSP00000328814
ENST00000333684
P07101 [Direct mapping]
Tyrosine 3-monooxygenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001666 [response to hypoxia]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0003007 [heart morphogenesis]
GO:0004511 [tyrosine 3-monooxygenase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006585 [dopamine biosynthetic process from tyrosine]
GO:0007507 [heart development]
GO:0007601 [visual perception]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0007626 [locomotory behavior]
GO:0008016 [regulation of heart contraction]
GO:0009653 [anatomical structure morphogenesis]
GO:0009887 [organ morphogenesis]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0016714 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen]
GO:0019899 [enzyme binding]
GO:0031410 [cytoplasmic vesicle]
GO:0033162 [melanosome membrane]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042416 [dopamine biosynthetic process]
GO:0042418 [epinephrine biosynthetic process]
GO:0042421 [norepinephrine biosynthetic process]
GO:0042423 [catecholamine biosynthetic process]
GO:0042462 [eye photoreceptor cell development]
GO:0043005 [neuron projection]
GO:0043204 [perikaryon]
GO:0043473 [pigmentation]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0048596 [embryonic camera-type eye morphogenesis]
GO:0055114 [oxidation-reduction process]
Show all
403 aa
44.9 kDa
No 0

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