Fields »
ABOUT
HELP
BLOG
FAHD1

GENERAL INFORMATION

Gene name

 FAHD1

Gene description

 Fumarylacetoacetate hydrolase domain containing 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression with a granular pattern in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 3 antibodies.
HPA043226 , HPA043534 , CAB025530
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA043226
HPA043534
CAB025530

GENE INFORMATION

Gene name

 FAHD1 (HGNC Symbol)

Synonyms

 C16orf36, DKFZP566J2046

Description

 Fumarylacetoacetate hydrolase domain containing 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 1826941 - 1840207

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180185 (version 83.38)

Entrez gene

 81889

UniProt

 Q6P587 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6P587

Antibodypedia

 FAHD1 antibodies

PROTEIN BROWSER
FAHD1-001
FAHD1-002
FAHD1-003
FAHD1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FAHD1-001
ENSP00000398053
ENST00000427358
Q6P587 [Direct mapping]
Acylpyruvase FAHD1, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Lyases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0008152 [metabolic process]
GO:0008948 [oxaloacetate decarboxylase activity]
GO:0018773 [acetylpyruvate hydrolase activity]
GO:0034545 [fumarylpyruvate hydrolase activity]
GO:0046872 [metal ion binding]
GO:0047621 [acylpyruvate hydrolase activity]
Show all
 224 aa
24.8 kDa 		No 0
FAHD1-002
ENSP00000372114
ENST00000382668
Q6P587 [Direct mapping]
Acylpyruvase FAHD1, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Lyases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0008152 [metabolic process]
GO:0008948 [oxaloacetate decarboxylase activity]
GO:0018773 [acetylpyruvate hydrolase activity]
GO:0034545 [fumarylpyruvate hydrolase activity]
GO:0046872 [metal ion binding]
GO:0047621 [acylpyruvate hydrolase activity]
Show all
 226 aa
24.9 kDa 		No 0
FAHD1-003
ENSP00000372112
ENST00000382666
Q6P587 [Direct mapping]
Acylpyruvase FAHD1, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Lyases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005829 [cytosol]
GO:0008152 [metabolic process]
GO:0008948 [oxaloacetate decarboxylase activity]
GO:0018773 [acetylpyruvate hydrolase activity]
GO:0034545 [fumarylpyruvate hydrolase activity]
GO:0046872 [metal ion binding]
GO:0047621 [acylpyruvate hydrolase activity]
Show all
 248 aa
27.1 kDa 		No 0
FAHD1-201
ENSP00000482534
ENST00000615972
Q6P587 [Direct mapping]
Acylpyruvase FAHD1, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Lyases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0008152 [metabolic process]
GO:0008948 [oxaloacetate decarboxylase activity]
GO:0018773 [acetylpyruvate hydrolase activity]
GO:0034545 [fumarylpyruvate hydrolase activity]
GO:0046872 [metal ion binding]
GO:0047621 [acylpyruvate hydrolase activity]
Show all
 248 aa
27.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.