Expression of TDRP in cancer - Summary - The Human Protein Atlas

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TDRP

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TDRP
Gene description	Testis development related protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BEWO)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA008462
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and pancreatic cancer (favourable).
Endometrial cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008462

GENE INFORMATION
Gene name	TDRP (HGNC Symbol)
Synonyms	C8orf42, INM01, TDRP1, TDRP2
Description	Testis development related protein (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	p23.3
Chromosome location (bp)	489792 - 545781
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180190 (version 83.38)
Entrez gene	157695
UniProt	Q86YL5 (UniProt - Evidence at protein level)
neXtProt	NX_Q86YL5
Antibodypedia	TDRP antibodies

PROTEIN BROWSER

TDRP-001	TDRP-002	TDRP-201	TDRP-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TDRP-001 ENSP00000315111 ENST00000324079	Q86YL5 [Direct mapping] Testis development-related protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007283 [spermatogenesis] Show all	185 aa 20.4 kDa	No	0
TDRP-002 ENSP00000430325 ENST00000523656	Q86YL5 [Direct mapping] Testis development-related protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007283 [spermatogenesis] Show all	198 aa 22.3 kDa	No	0
TDRP-201 ENSP00000408126 ENST00000427263	Q86YL5 [Direct mapping] Testis development-related protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007283 [spermatogenesis] Show all	198 aa 22.3 kDa	No	0
TDRP-202 ENSP00000479558 ENST00000613071	Q86YL5 [Direct mapping] Testis development-related protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007283 [spermatogenesis] Show all	185 aa 20.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.