Expression of CCDC43 in cancer - Summary - The Human Protein Atlas

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CCDC43

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCDC43
Gene description	Coiled-coil domain containing 43
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most cell types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA023391
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable), liver cancer (unfavourable) and pancreatic cancer (unfavourable).
Head and neck cancer p<0.001 Liver cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA023391

GENE INFORMATION
Gene name	CCDC43 (HGNC Symbol)
Synonyms	FLJ31795
Description	Coiled-coil domain containing 43 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q21.31
Chromosome location (bp)	44673069 - 44689779
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180329 (version 83.38)
Entrez gene	124808
UniProt	Q96MW1 (UniProt - Evidence at protein level)
neXtProt	NX_Q96MW1
Antibodypedia	CCDC43 antibodies

PROTEIN BROWSER

CCDC43-001	CCDC43-002	CCDC43-003	CCDC43-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC43-001 ENSP00000323782 ENST00000315286	Q96MW1 [Direct mapping] Coiled-coil domain-containing protein 43 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	224 aa 25.2 kDa	No	0
CCDC43-002 ENSP00000467630 ENST00000588210	Q86WV7 [Direct mapping] CCDC43 protein; Coiled-coil domain-containing protein 43 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	227 aa 25.6 kDa	No	0
CCDC43-003 ENSP00000400845 ENST00000457422	Q96MW1 [Direct mapping] Coiled-coil domain-containing protein 43 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	154 aa 16.8 kDa	No	0
CCDC43-005 ENSP00000468079 ENST00000588687	K7ER24 [Direct mapping] Coiled-coil domain-containing protein 43 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 11.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.