Expression of TIGD2 in cancer - Summary - The Human Protein Atlas

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TIGD2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TIGD2
Gene description	Tigger transposable element derived 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA054844
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable) and urothelial cancer (favourable).
Colorectal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA054844

GENE INFORMATION
Gene name	TIGD2
Synonyms
Description	Tigger transposable element derived 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q22.1
Chromosome location (bp)	89111500 - 89114899
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180346 (version 83.38)
Entrez gene	166815
UniProt	Q4W5G0 (UniProt - Inferred from homology)
neXtProt	NX_Q4W5G0
Antibodypedia	TIGD2 antibodies

PROTEIN BROWSER

TIGD2-001	TIGD2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TIGD2-001 ENSP00000486687 ENST00000603357	Q4W5G0 [Direct mapping] Tigger transposable element-derived protein 2 V9HWD1 [Target identity:100%; Query identity:100%] Epididymis luminal protein 106; Tigger transposable element derived 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005634 [nucleus] Show all	525 aa 59.6 kDa	No	0
TIGD2-201 ENSP00000317170 ENST00000317005	Q4W5G0 [Direct mapping] Tigger transposable element-derived protein 2 V9HWD1 [Target identity:100%; Query identity:100%] Epididymis luminal protein 106; Tigger transposable element derived 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005634 [nucleus] Show all	525 aa 59.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.