Expression of CCDC66 in cancer - Summary - The Human Protein Atlas

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CCDC66

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCDC66
Gene description	Coiled-coil domain containing 66
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and/or membranous expression in selected tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA044185
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044185

GENE INFORMATION
Gene name	CCDC66 (HGNC Symbol)
Synonyms	DKFZp686C0433
Description	Coiled-coil domain containing 66 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p14.3
Chromosome location (bp)	56557161 - 56621818
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180376 (version 83.38)
Entrez gene	285331
UniProt	A2RUB6 (UniProt - Evidence at protein level)
neXtProt	NX_A2RUB6
Antibodypedia	CCDC66 antibodies

PROTEIN BROWSER

CCDC66-001	CCDC66-002	CCDC66-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC66-001 ENSP00000378167 ENST00000394672	A2RUB6 [Direct mapping] Coiled-coil domain-containing protein 66 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0046548 [retinal rod cell development] GO:0050908 [detection of light stimulus involved in visual perception] GO:0060060 [post-embryonic retina morphogenesis in camera-type eye] Show all	948 aa 109.4 kDa	No	0
CCDC66-002 ENSP00000326050 ENST00000326595	A2RUB6 [Direct mapping] Coiled-coil domain-containing protein 66 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all		914 aa 105.6 kDa	No	0
CCDC66-008 ENSP00000401451 ENST00000422222	C9JYB8 [Direct mapping] Coiled-coil domain-containing protein 66 Show all	Predicted intracellular proteins Show all		633 aa 72.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.