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HMHA1

GENERAL INFORMATION

Gene name

 HMHA1

Gene description

 Histocompatibility (minor) HA-1

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (U-266/70)
HPA (normal tissue):Tissue enhanced (appendix, lymph node, spleen)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 High expression in immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA019816
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and head and neck cancer (favourable).
Endometrial cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA019816

GENE INFORMATION

Gene name

 HMHA1 (HGNC Symbol)

Synonyms

 ARHGAP45, HA-1, KIAA0223

Description

 Histocompatibility (minor) HA-1 (HGNC Symbol)

Entrez gene summary

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 1065923 - 1086628

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180448 (version 83.38)

Entrez gene

 23526

UniProt

 Q92619 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92619

Antibodypedia

 HMHA1 antibodies

PROTEIN BROWSER
HMHA1-001
HMHA1-002
HMHA1-003
HMHA1-004
HMHA1-005
HMHA1-007
HMHA1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HMHA1-001
ENSP00000439601
ENST00000539243
Q92619 [Direct mapping]
Minor histocompatibility protein HA-1 Minor histocompatibility antigen HA-1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
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 1152 aa
126.5 kDa 		Yes 0
HMHA1-002
ENSP00000316772
ENST00000313093
Q92619 [Direct mapping]
Minor histocompatibility protein HA-1 Minor histocompatibility antigen HA-1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
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 1136 aa
124.6 kDa 		No 0
HMHA1-003
ENSP00000466401
ENST00000590214
K7EM85 [Direct mapping]
Minor histocompatibility protein HA-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
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 1163 aa
127.6 kDa 		No 0
HMHA1-004
ENSP00000438979
ENST00000543365
F5H1R4 [Direct mapping]
Minor histocompatibility protein HA-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
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 1019 aa
112.5 kDa 		No 0
HMHA1-005
ENSP00000468607
ENST00000590577
K7ES92 [Direct mapping]
Minor histocompatibility protein HA-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
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 771 aa
84.6 kDa 		No 0
HMHA1-007
ENSP00000468615
ENST00000586866
K7ES98 [Direct mapping]
Minor histocompatibility protein HA-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
Show all
 1140 aa
125.1 kDa 		No 0
HMHA1-010
ENSP00000467741
ENST00000587186
K7EQA4 [Direct mapping]
Minor histocompatibility protein HA-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 170 aa
17.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.