Expression of DEFB119 in cancer - Summary - The Human Protein Atlas

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DEFB119

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DEFB119
Gene description	Defensin, beta 119
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (testis cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (epididymis, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in seminiferous ducts in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 1 antibody. HPA043059
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043059

GENE INFORMATION
Gene name	DEFB119 (HGNC Symbol)
Synonyms	DEFB-19, DEFB-20, DEFB120
Description	Defensin, beta 119 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Chromosome	20
Cytoband	q11.21
Chromosome location (bp)	31377164 - 31390603
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180483 (version 83.38)
Entrez gene	245932
UniProt	Q8N690 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N690
Antibodypedia	DEFB119 antibodies

PROTEIN BROWSER

DEFB119-001	DEFB119-003	DEFB119-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DEFB119-001 ENSP00000345768 ENST00000339144	Q8N690 [Direct mapping] Beta-defensin 119 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0009986 [cell surface] GO:0042742 [defense response to bacterium] GO:0045087 [innate immune response] Show all	43 aa 4.7 kDa	Yes	0
DEFB119-003 ENSP00000365499 ENST00000376321	Q8N690 [Direct mapping] Beta-defensin 119 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005576 [extracellular region] GO:0009986 [cell surface] GO:0042742 [defense response to bacterium] GO:0045087 [innate immune response] Show all	84 aa 9.8 kDa	Yes	0
DEFB119-004 ENSP00000365492 ENST00000376315	Q8N690 [Direct mapping] Beta-defensin 119 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0009986 [cell surface] GO:0042742 [defense response to bacterium] GO:0045087 [innate immune response] Show all	88 aa 10.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.