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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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BHLHA15
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

BHLHA15

Gene description

Basic helix-loop-helix family, member a15

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enhanced (prostate cancer)
HPA (cell line):Group enriched (Karpas-707, RPMI-8226, U-266/70)
HPA (normal tissue):Group enriched (pancreas, salivary gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in glandular cells in stomach, salivary gland, exocrine pancreas and a subset of non-germinal center cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA047834 , CAB034083
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enhanced (prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY

HPA047834
CAB034083

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A few cases of adenocarcinomas of lung showed moderate nuclear positivity. Remaining malignant tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A fraction of tumor cells in several squamous cell carcinomas and a few urothelial cancers displayed strong cytoplasmic immunoreactivity. Remaining cancer cells were negative.

GENE INFORMATION

Gene name

BHLHA15 (HGNC Symbol)

Synonyms

bHLHa15, BHLHB8, MIST1

Description

Basic helix-loop-helix family, member a15 (HGNC Symbol)

Entrez gene summary

Chromosome

7

Cytoband

q21.3

Chromosome location (bp)

98211427 - 98212979

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000180535 (version 83.38)

Entrez gene

168620

UniProt

Q7RTS1 (UniProt - Evidence at protein level)

neXtProt

NX_Q7RTS1

Antibodypedia

BHLHA15 antibodies

PROTEIN BROWSER

BHLHA15-001
BHLHA15-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BHLHA15-001
ENSP00000326391
ENST00000314018
Q7RTS1 [Direct mapping]
Class A basic helix-loop-helix protein 15
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Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Show all
GO:0005634 [nucleus]
GO:0010832 [negative regulation of myotube differentiation]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0046983 [protein dimerization activity]
Show all
189 aa
20.8 kDa
No 0
BHLHA15-003
ENSP00000476312
ENST00000609256
Q7RTS1 [Direct mapping]
Class A basic helix-loop-helix protein 15
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006851 [mitochondrial calcium ion transport]
GO:0007030 [Golgi organization]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0010832 [negative regulation of myotube differentiation]
GO:0019722 [calcium-mediated signaling]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042593 [glucose homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0048312 [intracellular distribution of mitochondria]
GO:0048469 [cell maturation]
Show all
189 aa
20.8 kDa
No 0

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