Tissue expression of SLC47A2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLC47A2
Gene description	Solute carrier family 47 (multidrug and toxin extrusion), member 2
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (fallopian tube, kidney)
GTEx:	Tissue enriched (kidney)
FANTOM5:	Tissue enriched (kidney)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (fallopian tube, kidney)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (kidney)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (kidney)

GENE INFORMATION
Gene name	SLC47A2 (HGNC Symbol)
Synonyms	FLJ31196, MATE2, MATE2-K
Description	Solute carrier family 47 (multidrug and toxin extrusion), member 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	19678288 - 19718979
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180638 (version 83.38)
Entrez gene	146802
UniProt	Q86VL8 (UniProt - Evidence at protein level)
neXtProt	NX_Q86VL8
Antibodypedia	SLC47A2 antibodies

PROTEIN BROWSER

SLC47A2-001	SLC47A2-002	SLC47A2-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC47A2-001 ENSP00000338084 ENST00000350657	Q86VL8 [Direct mapping] Multidrug and toxin extrusion protein 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005886 [plasma membrane] GO:0006855 [drug transmembrane transport] GO:0015238 [drug transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	580 aa 62.7 kDa	No	>9
SLC47A2-002 ENSP00000326671 ENST00000325411	Q86VL8 [Direct mapping] Multidrug and toxin extrusion protein 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005886 [plasma membrane] GO:0006855 [drug transmembrane transport] GO:0015238 [drug transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	602 aa 65.1 kDa	No	>9
SLC47A2-008 ENSP00000391848 ENST00000433844	C9JAE6 [Direct mapping] Multidrug and toxin extrusion protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0006855 [drug transmembrane transport] GO:0015238 [drug transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	363 aa 39.3 kDa	No	>9