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YOD1

GENERAL INFORMATION

Gene name

 YOD1

Gene description

 YOD1 deubiquitinase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HEL, K-562)
HPA (normal tissue):Tissue enhanced (bone marrow)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA028400 , HPA028439
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028400
HPA028439

GENE INFORMATION

Gene name

 YOD1 (HGNC Symbol)

Synonyms

 DKFZp451J1719, DUBA8, OTUD2

Description

 YOD1 deubiquitinase (HGNC Symbol)

Entrez gene summary

 Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 207043849 - 207052980

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180667 (version 83.38)

Entrez gene

 55432

UniProt

 Q5VVQ6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5VVQ6

Antibodypedia

 YOD1 antibodies

PROTEIN BROWSER
YOD1-001
YOD1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
YOD1-001
ENSP00000356051
ENST00000367084
Q5VVQ6 [Direct mapping]
Ubiquitin thioesterase OTU1
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035523 [protein K29-linked deubiquitination]
GO:0035871 [protein K11-linked deubiquitination]
GO:0046872 [metal ion binding]
GO:0061578 [Lys63-specific deubiquitinase activity]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol]
GO:1904265 [ubiquitin-specific protease activity involved in negative regulation of retrograde protein transport, ER to cytosol]
GO:1990167 [protein K27-linked deubiquitination]
GO:1990168 [protein K33-linked deubiquitination]
GO:1990380 [Lys48-specific deubiquitinase activity]
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 304 aa
34 kDa 		No 0
YOD1-002
ENSP00000326813
ENST00000315927
Q5VVQ6 [Direct mapping]
Ubiquitin thioesterase OTU1
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035523 [protein K29-linked deubiquitination]
GO:0035871 [protein K11-linked deubiquitination]
GO:0046872 [metal ion binding]
GO:0061578 [Lys63-specific deubiquitinase activity]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol]
GO:1904265 [ubiquitin-specific protease activity involved in negative regulation of retrograde protein transport, ER to cytosol]
GO:1990167 [protein K27-linked deubiquitination]
GO:1990168 [protein K33-linked deubiquitination]
GO:1990380 [Lys48-specific deubiquitinase activity]
Show all
 348 aa
38.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.