Expression of CLRN3 in cancer - Summary - The Human Protein Atlas

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CLRN3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CLRN3
Gene description	Clarin 3
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (colorectal cancer, liver cancer, pancreatic cancer, renal cancer, stomach cancer)
HPA (cell line):	Cell line enriched (CACO-2)
HPA (normal tissue):	Group enriched (colon, duodenum, gallbladder, kidney, liver, rectum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in the intestinal tract, kidney, liver and gallbladder.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA014482
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PROGNOSTIC SUMMARY
Prognostic marker in stomach cancer (favourable).
Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (colorectal cancer, liver cancer, pancreatic cancer, renal cancer, stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014482

GENE INFORMATION
Gene name	CLRN3 (HGNC Symbol)
Synonyms	MGC32871, TMEM12, USH3AL1
Description	Clarin 3 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	q26.2
Chromosome location (bp)	127877841 - 127892947
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180745 (version 83.38)
Entrez gene	119467
UniProt	Q8NCR9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NCR9
Antibodypedia	CLRN3 antibodies

PROTEIN BROWSER

CLRN3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLRN3-001 ENSP00000357660 ENST00000368671	Q8NCR9 [Direct mapping] Clarin-3 Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	226 aa 25.3 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.