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ZDHHC20

GENERAL INFORMATION

Gene name

 ZDHHC20

Gene description

 Zinc finger, DHHC-type containing 20

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA014483 , HPA014702
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA014483
HPA014702

GENE INFORMATION

Gene name

 ZDHHC20 (HGNC Symbol)

Synonyms

 FLJ25952

Description

 Zinc finger, DHHC-type containing 20 (HGNC Symbol)

Entrez gene summary

Chromosome

 13

Cytoband

 q12.11

Chromosome location (bp)

 21372573 - 21459370

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180776 (version 83.38)

Entrez gene

 253832

UniProt

 Q5W0Z9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5W0Z9

Antibodypedia

 ZDHHC20 antibodies

PROTEIN BROWSER
ZDHHC20-001
ZDHHC20-201
ZDHHC20-202
ZDHHC20-203
ZDHHC20-204

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZDHHC20-001
ENSP00000383433
ENST00000400590
Q5W0Z9 [Direct mapping]
Probable palmitoyltransferase ZDHHC20
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006612 [protein targeting to membrane]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016409 [palmitoyltransferase activity]
GO:0018230 [peptidyl-L-cysteine S-palmitoylation]
GO:0018345 [protein palmitoylation]
GO:0019706 [protein-cysteine S-palmitoyltransferase activity]
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 365 aa
42.3 kDa 		No 4
ZDHHC20-201
ENSP00000313583
ENST00000320220
Q5W0Z9 [Direct mapping]
Probable palmitoyltransferase ZDHHC20
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006612 [protein targeting to membrane]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016409 [palmitoyltransferase activity]
GO:0018230 [peptidyl-L-cysteine S-palmitoylation]
GO:0018345 [protein palmitoylation]
GO:0019706 [protein-cysteine S-palmitoyltransferase activity]
Show all
 320 aa
37.6 kDa 		No 4
ZDHHC20-202
ENSP00000371905
ENST00000382466
Q5W0Z9 [Direct mapping]
Probable palmitoyltransferase ZDHHC20
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006612 [protein targeting to membrane]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016409 [palmitoyltransferase activity]
GO:0018230 [peptidyl-L-cysteine S-palmitoylation]
GO:0018345 [protein palmitoylation]
GO:0019706 [protein-cysteine S-palmitoyltransferase activity]
Show all
 354 aa
41.1 kDa 		No 4
ZDHHC20-203
ENSP00000401232
ENST00000415724
Q5W0Z9 [Direct mapping]
Probable palmitoyltransferase ZDHHC20
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006612 [protein targeting to membrane]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016409 [palmitoyltransferase activity]
GO:0018230 [peptidyl-L-cysteine S-palmitoylation]
GO:0018345 [protein palmitoylation]
GO:0019706 [protein-cysteine S-palmitoyltransferase activity]
Show all
 365 aa
42.3 kDa 		No 4
ZDHHC20-204
ENSP00000443236
ENST00000542645
B4DRN8 [Direct mapping]
Palmitoyltransferase
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0019706 [protein-cysteine S-palmitoyltransferase activity]
Show all
 292 aa
33.7 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.