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MAP3K15

GENERAL INFORMATION

Gene name

 MAP3K15

Gene description

 Mitogen-activated protein kinase kinase kinase 15

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (A549, HEK93, HEL, REH)
HPA (normal tissue):Tissue enriched (adrenal gland)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 MAP3K15 (HGNC Symbol)

Synonyms

 ASK3, bA723P2.3, FLJ16518

Description

 Mitogen-activated protein kinase kinase kinase 15 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010]

Chromosome

 X

Cytoband

 p22.12

Chromosome location (bp)

 19360056 - 19515261

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180815 (version 83.38)

Entrez gene

 389840

UniProt

 Q6ZN16 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6ZN16

Antibodypedia

 MAP3K15 antibodies

PROTEIN BROWSER
MAP3K15-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAP3K15-001
ENSP00000345629
ENST00000338883
Q6ZN16 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 15
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0046872 [metal ion binding]
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 1313 aa
147.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.