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PPA1

GENERAL INFORMATION

Gene name

 PPA1

Gene description

 Pyrophosphatase (inorganic) 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA019878 , HPA020096
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019878
HPA020096

GENE INFORMATION

Gene name

 PPA1 (HGNC Symbol)

Synonyms

 IOPPP, PP, PP1, Ppase, SID6-8061

Description

 Pyrophosphatase (inorganic) 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q22.1

Chromosome location (bp)

 70202830 - 70233911

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180817 (version 83.38)

Entrez gene

 5464

UniProt

 Q15181 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15181

Antibodypedia

 PPA1 antibodies

PROTEIN BROWSER
PPA1-001
PPA1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPA1-001
ENSP00000362329
ENST00000373232
Q15181 [Direct mapping]
Inorganic pyrophosphatase
V9HWB5 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 66p; Pyrophosphatase (Inorganic) 1, isoform CRA_a
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding]
GO:0004427 [inorganic diphosphatase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006796 [phosphate-containing compound metabolic process]
GO:0010467 [gene expression]
GO:0016462 [pyrophosphatase activity]
GO:0070062 [extracellular exosome]
GO:0071344 [diphosphate metabolic process]
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 289 aa
32.7 kDa 		No 0
PPA1-201
ENSP00000486162
ENST00000625364
Q5SQT6 [Direct mapping]
Inorganic pyrophosphatase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding]
GO:0004427 [inorganic diphosphatase activity]
GO:0005737 [cytoplasm]
GO:0006796 [phosphate-containing compound metabolic process]
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 178 aa
20 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.