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HOXC10

GENERAL INFORMATION

Gene name

 HOXC10

Gene description

 Homeobox C10

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (AN3-CA, T-47d)
HPA (normal tissue):Group enriched (kidney, skeletal muscle, skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression at variable levels in several different tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA053919
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA053919

GENE INFORMATION

Gene name

 HOXC10 (HGNC Symbol)

Synonyms

 HOX3I

Description

 Homeobox C10 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 53985065 - 53990279

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180818 (version 83.38)

Entrez gene

 3226

UniProt

 Q9NYD6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NYD6

Antibodypedia

 HOXC10 antibodies

PROTEIN BROWSER
HOXC10-001
HOXC10-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HOXC10-001
ENSP00000307321
ENST00000303460
Q9NYD6 [Direct mapping]
Homeobox protein Hox-C10
Q53XI4 [Target identity:100%; Query identity:100%]
Homeo box C10; Homeobox C10, isoform CRA_a; cDNA, FLJ94360, Homo sapiens homeo box C10 (HOXC10), mRNA
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001501 [skeletal system development]
GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008284 [positive regulation of cell proliferation]
GO:0009952 [anterior/posterior pattern specification]
GO:0009954 [proximal/distal pattern formation]
GO:0019907 [cyclin-dependent protein kinase activating kinase holoenzyme complex]
GO:0021520 [spinal cord motor neuron cell fate specification]
GO:0030326 [embryonic limb morphogenesis]
GO:0043565 [sequence-specific DNA binding]
GO:0050905 [neuromuscular process]
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 342 aa
38.1 kDa 		No 0
HOXC10-002
ENSP00000421946
ENST00000515593
D6RAG4 [Direct mapping]
Homeobox protein Hox-C10
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 127 aa
13.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.